Suarez, Isabelle, Rohr, Samuel, Stecher, Melanie, Lehmann, Clara, Winter, Sandra, Jung, Norma, Priesner, Vanessa, Berger, Melanie, Wyen, Christoph, Augustin, Max, Malin, Jakob J. ORCID: 0000-0002-2989-0436, Fischer, Julia, Horn, Carola, Neuhann, Florian, Puesken, Michael, Plum, Georg, Faetkenheuer, Gerd and Rybniker, Jan . Plasma interferon-gamma-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis. Infection. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

Full text not available from this repository.

Abstract

Background With 1.5 million deaths worldwide in 2018, tuberculosis (TB) remains a major global public health problem. While pulmonary TB (PTB) is the most common manifestation, the proportion of extrapulmonary TB (EPTB) is increasing in low-burden countries. EPTB is a heterogeneous disease entity posing diagnostic and management challenges due to the lack of reliable biomarkers. In this study, we prospectively evaluated clinical data and treatment response which were correlated with different biomarkers. Methods The study was conducted at the University Hospital of Cologne. 20 patients with EPTB were enrolled. We analyzed plasma interferon-gamma-inducible protein 10 (IP-10) levels in plasma by ELISA for up to 12 months of treatment. In addition, the QuantiFERON(R)-TB Gold Plus (QFT(R) Plus) test was performed during the course of treatment. Clinical data were assessed prospectively and correlated with QFT(R) Plus and IP-10 levels. Results Plasma IP-10 levels were found to be significantly increased (p < 0.001) in patients with extensive disease compared to patients with limited disease (cervical lymph node TB) or healthy controls. In patients with clinically confirmed paradoxical reaction (PR), a further increase of IP-10 was noted. IFN-gamma measured by the QFT(R) Plus test did not decrease significantly during the course of treatment. Of note, in four EPTB patients (20%) without radiographic pulmonary involvement, sputum culture was positive for Mycobacterium tuberculosis. Conclusion Our data demonstrate that IP-10 may be a valuable biomarker for estimation of disease severity in EPTB and monitoring of the disease course in extensive forms. However, IP-10 may be less suitable for diagnosis and monitoring of EPTB patients with limited disease. The QFT(R) Plus test does not appear to be a suitable marker for therapy monitoring. Sputum should be examined in EPTB patients even in case of normal diagnostic imaging of the chest.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Suarez, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rohr, SamuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winter, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priesner, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Augustin, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malin, Jakob J.UNSPECIFIEDorcid.org/0000-0002-2989-0436UNSPECIFIED
Fischer, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhann, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puesken, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plum, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rybniker, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-312390
DOI: 10.1007/s15010-020-01541-1
Journal or Publication Title: Infection
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-0973
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RECONSTITUTION INFLAMMATORY SYNDROME; ACTIVE TUBERCULOSIS; LATENT TUBERCULOSIS; HIV; BIOMARKERMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31239

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item