Rheinwalt, Karl Peter, Drebber, Uta, Schierwagen, Robert, Klein, Sabine, Neumann, Ulf Peter, Ulmer, Tom Florian, Plamper, Andreas, Kroh, Andreas, Schipper, Sandra, Odenthal, Margarete, Uschner, Frank Erhard, Lingohr, Philipp, Trebicka, Jonel ORCID: 0000-0002-7028-3881 and Brol, Maximilian Joseph (2020). Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity. J. Clin. Med., 9 (11). BASEL: MDPI. ISSN 2077-0383

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Abstract

Background. Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients' weight loss. Data about the influence of Non-alcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods. This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (One Anastomosis-Mini Gastric Bypass (OAGB-MGB) or Roux-en-Y Gastric Bypass (RYGB)). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to No NAFLD, NAFL or NASH. Follow up data were collected at 3, 6 and 12 months. Results. In total, 49.7% of patients had NASH, while 41.3% had NAFL. Compared with the No NAFLD group, NAFL and NASH showed higher body-mass-index (BMI) at follow-up (6 months: 31.0 kg/m(2) vs. 36.8 kg/m(2) and 36.1 kg/m(2), 12 months: 27.0 kg/m(2) vs. 34.4 and 32.8 kg/m(2)) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%; 12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusions. Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after gastric bypass surgery. The mechanisms underlying this observation should be further studied.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rheinwalt, Karl PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drebber, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schierwagen, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumann, Ulf PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ulmer, Tom FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plamper, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroh, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schipper, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odenthal, MargareteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uschner, Frank ErhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lingohr, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trebicka, JonelUNSPECIFIEDorcid.org/0000-0002-7028-3881UNSPECIFIED
Brol, Maximilian JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-313024
DOI: 10.3390/jcm9113430
Journal or Publication Title: J. Clin. Med.
Volume: 9
Number: 11
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2077-0383
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SIMPLE NONINVASIVE INDEX; BARIATRIC SURGERY; SIGNIFICANT FIBROSIS; SLEEVE GASTRECTOMY; SCORING SYSTEM; VALIDATIONMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31302

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