Hopff, Sina M., Onambele, Liliane A., Brandenburg, Marc, Berkessel, Albrecht and Prokop, Aram (2020). Discovery of a cobalt (III) salen complex that induces apoptosis in Burkitt like lymphoma and leukemia cells, overcoming multidrug resistance in vitro. Bioorganic Chem., 104. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2120

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Abstract

A very small number of cobalt complexes is examined in oncology research. In this work, we investigate the cobalt (III) salen complex MBR-60 that turns out to be a promising anticancer drug. It induces apoptosis in Nalm6 leukemia and BJAB lymphoma cells and overcomes multidrug resistances by blocking the drug efflux pump P-glycoprotein. It further develops the apoptotic effects over the intrinsic pathway. An activation of caspase-3, caspase-8 and caspase-9 can be detected by western blot analysis. The independence of CD95 is shown by similar apoptotic inductions in BJAB and BJAB FADDdn cells. MBR-60 displays synergistic effects with daunorubicin and vincristine and has a selectivity to tumor cells. In comparison to the apoptotic effects of MBR-60 in BJAB lymphoma cells, the cobalt-free ligand 5 does not influence these cells. The research highlights that a cobalt complex has a therapeutic potential for cancer treating with a focus on drug-resistant tumors.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hopff, Sina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onambele, Liliane A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandenburg, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berkessel, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokop, AramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-313104
DOI: 10.1016/j.bioorg.2020.104193
Journal or Publication Title: Bioorganic Chem.
Volume: 104
Date: 2020
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication: SAN DIEGO
ISSN: 1090-2120
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HYDROLYTIC KINETIC RESOLUTION; DRUG-RESISTANCE; ORGANOMETALLIC COMPOUNDS; ALKYNE COMPLEXES; PROPYLENE-OXIDE; CANCER; MECHANISMS; CYTOTOXICITY; INHIBITION; CATALYSISMultiple languages
Biochemistry & Molecular Biology; Chemistry, OrganicMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31310

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