Universität zu Köln

Adler, Joana, Gerhardt, Felix, Wissmueller, Max, Adler, Christoph, Baldus, Stephan and Rosenkranz, Stephan (2020). Pulmonary hypertension associated with left-sided heart failure. Curr. Opin. Cardiol., 35 (6). S. 610 - 620. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1531-7080

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Abstract

Purpose of review Pulmonary hypertension is a common phenomenon in heart failure patients that is highly relevant for morbidity and outcome. Although postcapillary in nature, the pathophysiology of pulmonary hypertension in patients with heart failure with reduced or preserved ejection fraction is complex, and decisions about management strategies remain challenging. Recent findings Recently, the hemodynamic definitions and subclassification of postcapillary pulmonary hypertension have been revisited. The distinction between isolated postcapillary pulmonary hypertension (IpcPH) and combined post and precapillary pulmonary hypertension (CpcPH) and their definition are essential. Novel data on the prognostic impact of hemodynamic variables and right ventricular function highlight the importance of cardiopulmonary interaction in patients with left-sided heart failure (LHF). Furthermore, the impact of management strategies including medical therapy, remote hemodynamic monitoring, and interventional approaches on hemodynamics and outcome has recently been investigated. Here, we critically review recent developments and future considerations in this field, and highlight distinct treatment strategies targeting the underlying left heart condition, the pulmonary circulation, and/or impaired right ventricular function. Detailed hemodynamic characterization and proper phenotyping are essential for prognostication and the management of patients with pulmonary hypertension associated with LHF, both in clinical practice and when addressing research questions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Adler, Joana UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerhardt, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Wissmueller, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-313604
DOI:	10.1097/HCO.0000000000000791
Journal or Publication Title:	Curr. Opin. Cardiol.
Volume:	35
Number:	6
Page Range:	S. 610 - 620
Date:	2020
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1531-7080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRESERVED EJECTION FRACTION; PHOSPHODIESTERASE-5 INHIBITION; EXERCISE CAPACITY; PROGNOSTIC VALUE; ARTERY PRESSURE; DOUBLE-BLIND; HEMODYNAMICS; RIOCIGUAT; OUTCOMES; MULTICENTER Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31360