Ladigan-Badura, Swetlana, Vangala, Deepak B., Engel, Christoph ORCID: 0000-0002-7247-282X, Bucksch, Karolin, Hueneburg, Robert, Perne, Claudia, Nattermann, Jacob, Steinke-Lange, Verena, Rahner, Nils, Schackert, Hans K., Weitz, Juergen, Kloor, Matthias, Kuhlkamp, Judith, Moeslein, Gabriela, Strassburg, Christian, Morak, Monika, Holinski-Feder, Elke, Buettner, Reinhard, Aretz, Stefan, Loeffler, Markus, Schmiegel, Wolff, Pox, Christian and Schulmann, Karsten (2021). Value of uppergastrointestinalendoscopy for gastric cancer surveillance in patients with Lynch syndrome. Int. J. Cancer, 148 (1). S. 106 - 115. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of theGerman Consortium for Familial Intestinal Cancer. In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty-nine GC events were observed in 47 patients.MLH1(n = 21) andMSH2(n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early-stage disease (UICC I) than GCs detected through symptoms (83% vs 25%;P= .0231). Thirty-two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28-66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ladigan-Badura, SwetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vangala, Deepak B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Bucksch, KarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hueneburg, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perne, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nattermann, JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinke-Lange, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahner, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schackert, Hans K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weitz, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kloor, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhlkamp, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeslein, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strassburg, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morak, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holinski-Feder, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aretz, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loeffler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmiegel, WolffUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pox, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulmann, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-315155
DOI: 10.1002/ijc.33294
Journal or Publication Title: Int. J. Cancer
Volume: 148
Number: 1
Page Range: S. 106 - 115
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NONPOLYPOSIS COLORECTAL-CANCER; MSH2 MUTATION CARRIERS; EXTRACOLONIC CANCERS; RISK; MLH1; MANAGEMENT; FAMILIES; SPECTRUM; INDIVIDUALS; FREQUENCYMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31515

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