Rinschen, Markus M. and Saez-Rodriguez, Julio ORCID: 0000-0002-8552-8976 . The tissue proteome in the multi-omic landscape of kidney disease. Nat. Rev. Nephrol.. BERLIN: NATURE RESEARCH. ISSN 1759-507X

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Abstract

Kidney research is entering an era of 'big data' and molecular omics data can provide comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics, proteomics and metabolomics generate data that relate more directly to the pathological symptoms and clinical parameters observed in patients. Owing to its complexity, the proteome still holds many secrets, but has great potential for the identification of drug targets. Proteomics can provide information about protein synthesis, modification and degradation, as well as insight into the physical interactions between proteins, and between proteins and other biomolecules. Thus far, proteomics in nephrology has largely focused on the discovery and validation of biomarkers, but the systematic analysis of the nephroproteome can offer substantial additional insights, including the discovery of mechanisms that trigger and propagate kidney disease. Moreover, proteome acquisition might provide a diagnostic tool that complements the assessment of a kidney biopsy sample by a pathologist. Such applications are becoming increasingly feasible with the development of high-throughput and high-coverage technologies, such as versatile mass spectrometry-based techniques and protein arrays, and encourage further proteomics research in nephrology. Technological advances continue to expand the use of proteomics in medicine. In this Review, the authors discuss proteomics research findings in nephrology and the potential, as well as the limitations, of using proteomics techniques to uncover disease mechanisms and develop new therapeutic strategies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rinschen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saez-Rodriguez, JulioUNSPECIFIEDorcid.org/0000-0002-8552-8976UNSPECIFIED
URN: urn:nbn:de:hbz:38-315567
DOI: 10.1038/s41581-020-00348-5
Journal or Publication Title: Nat. Rev. Nephrol.
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 1759-507X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
B MEMBER 9; PHOSPHOPROTEOMIC ANALYSIS; DIABETIC-NEPHROPATHY; URINARY PEPTIDOMICS; PROFILING REVEALS; CONNECTIVITY MAP; SYSTEMS BIOLOGY; CELL SUBSETS; MASS; GENEMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31556

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