Universität zu Köln

Abassi, Leila and Cicin-Sain, Luka (2020). The avid competitors of memory inflation. Curr. Opin. Virol., 44. S. 162 - 169. OXFORD: ELSEVIER SCI LTD. ISSN 1879-6265

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Abstract

Cytomegaloviruses (CMV) coevolve with their hosts and latently persist in the vast majority of adult mammals. Therefore, persistent T-cell responses to CMV antigens during virus latency offer a fascinating perspective on the evolution of the T-cell repertoire in natural settings. We addressed here the life-long interactions between CMV antigens presented on MHC-I molecules and the CD8 T-cell response. We present the mechanistic evidence from the murine model of CMV infection and put it in context of clinical laboratory results. We will highlight the remarkable parallels in T-cell responses between the two biological systems, and focus in particular on memory inflation as a result of competitive processes, both between viral antigenic peptides and between T-cell receptors on the host's cytotoxic lymphocytes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Abassi, Leila UNSPECIFIED UNSPECIFIED UNSPECIFIED Cicin-Sain, Luka UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315955
DOI:	10.1016/j.coviro.2020.08.007
Journal or Publication Title:	Curr. Opin. Virol.
Volume:	44
Page Range:	S. 162 - 169
Date:	2020
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-6265
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CD8(+) T-CELLS; HUMAN CYTOMEGALOVIRUS; CELLULAR-IMMUNITY; GENE-EXPRESSION; PROTECTION; INFECTION; RESPONSES; LATENCY; IMMUNODOMINANCE; RECONSTITUTION Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31595