Kresken, Michael, Korte-Berwanger, Miriam, Gatermann, Soeren G., Pfeifer, Yvonne, Pfennigwerth, Niels, Seifert, Harald and Werner, Guido (2020). In vitro activity of cefiderocol against aerobic Gram-negative bacterial pathogens from Germany. Int. J. Antimicrob. Agents, 56 (4). AMSTERDAM: ELSEVIER. ISSN 1872-7913

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Abstract

Objectives: Cefiderocol (CID), also known as S-649266, a novel siderophore cephalosporin, possesses potent activity against multidrug-resistant aerobic Gram-negative bacteria (GNB). This study aimed to determine the in vitro activity of CID against two different sets of GNB: i) a random sample of 213 clinical isolates, including 17 extended-spectrum beta-lactamase (ESBL) producers, obtained from intensive care unit patients with nosocomial infections collected during a multicentre surveillance study (set I); and ii) a group of 59 challenge GNB producing various types of carbapenemases (CP; set II). Methods: Minimum inhibitory concentrations (MICs) were determined using the microdilution method according to the standard ISO 20776-1. Iron-depleted medium was used for testing CID. Results: CID inhibited 97.2% of set I isolates at the EUCAST susceptibility breakpoint of <= 2 mg/L. The concentrations of CID inhibiting 50% and 90% (MIC50/90) of the Enterobacterales isolates (n = 146) were 0.12/1.0 mg/L, with ESBL-positive isolates tending to exhibit higher MICs than ESBL-negative isolates to CID. MIC50/90 values of CID for isolates of the Acinetobacter baumannii group (n = 13) and Pseudomonas aeruginosa (n = 54) were 0.06/0.12 mg/L and 0.12/0.5 mg/L, respectively. Further, CID inhibited 88.1% of set II CP-producing isolates at <= 2 mg/L. All seven class D CP-producing Acinetobacter baumannii were inhibited at < 0.25 mg/L. MIC50/90 values for CP-producing Enterobacterales (n = 30) and Pseudomonas aeruginosa (n = 22) were 1/4 mg/L and 0.5/2 mg/L, respectively. Conclusion: CID showed potent activity against Acinetobacter baumannii, Enterobacterales and Pseudomonas aeruginosa, including CP-producing isolates. Overall, CID inhibited 259 of 272 (95.2%) GNB at <= 2 mg/L. (C) 2020 The Authors. Published by Elsevier Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kresken, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korte-Berwanger, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gatermann, Soeren G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeifer, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfennigwerth, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-317568
DOI: 10.1016/j.ijantimicag.2020.106128
Journal or Publication Title: Int. J. Antimicrob. Agents
Volume: 56
Number: 4
Date: 2020
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1872-7913
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SIDEROPHORE CEPHALOSPORIN; ANTIBACTERIAL ACTIVITY; RESISTANCE; S-649266Multiple languages
Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31756

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