Brandao, Bruna B., Madsen, Soren ORCID: 0000-0002-1585-7862, Rabiee, Atefeh, Oliverio, Matteo ORCID: 0000-0002-7969-2796, Ruiz, Gabriel P., Ferrucci, Danilo L., Branquinho, Jessica L., Razolli, Daniela, Pinto, Silas, Nielsen, Thomas S., Festuccia, William T., Martins, Adriano S., Guerra, Beatriz A., Knittel, Thiago L., Sogaard, Ditte, Larsen, Steen ORCID: 0000-0002-5170-4337, Helge, Jorn W., Brandauer, Josef, Velloso, Licio A., Emanuelli, Brice ORCID: 0000-0001-5795-5666, Kornfeld, Jan-Wilhelm ORCID: 0000-0002-6802-4442, Kahn, C. Ronald, Vienberg, Sara G., Zierath, Juleen R., Treebak, Jonas T. and Mori, Marcelo A. (2020). Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. Proc. Natl. Acad. Sci. U. S. A., 117 (38). S. 23932 - 23942. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Brandao, Bruna B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Madsen, SorenUNSPECIFIEDorcid.org/0000-0002-1585-7862UNSPECIFIED
Rabiee, AtefehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oliverio, MatteoUNSPECIFIEDorcid.org/0000-0002-7969-2796UNSPECIFIED
Ruiz, Gabriel P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrucci, Danilo L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Branquinho, Jessica L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Razolli, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, SilasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nielsen, Thomas S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Festuccia, William T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martins, Adriano S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guerra, Beatriz A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knittel, Thiago L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sogaard, DitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larsen, SteenUNSPECIFIEDorcid.org/0000-0002-5170-4337UNSPECIFIED
Helge, Jorn W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandauer, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Velloso, Licio A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emanuelli, BriceUNSPECIFIEDorcid.org/0000-0001-5795-5666UNSPECIFIED
Kornfeld, Jan-WilhelmUNSPECIFIEDorcid.org/0000-0002-6802-4442UNSPECIFIED
Kahn, C. RonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vienberg, Sara G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zierath, Juleen R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treebak, Jonas T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mori, Marcelo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-318609
DOI: 10.1073/pnas.2011243117
Journal or Publication Title: Proc. Natl. Acad. Sci. U. S. A.
Volume: 117
Number: 38
Page Range: S. 23932 - 23942
Date: 2020
Publisher: NATL ACAD SCIENCES
Place of Publication: WASHINGTON
ISSN: 0027-8424
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACTIVATED PROTEIN-KINASE; HUMAN SKELETAL-MUSCLE; ENDURANCE EXERCISE; GENE-EXPRESSION; FUEL SELECTION; INSULIN ACTION; WHITE FAT; AMPK; ACID; GLUCOSEMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31860

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