Seifert, Harald, Mueller, Carina, Stefanik, Danuta, Higgins, Paul G. ORCID: 0000-0001-8677-9454, Miller, Alita and Kresken, Michael (2020). In vitro activity of sulbactam/durlobactam against global isolates of carbapenem-resistant Acinetobacter baumannii. J. Antimicrob. Chemother., 75 (9). S. 2616 - 2622. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Objectives: To evaluate the activity of the novel broad-spectrum serine beta-lactamase inhibitor durlobactam (ETX2514) combined with sulbactam against global isolates of carbapenem-resistant Acinetobacter baumannii with defined carbapenem resistance mechanisms compared with reference antimicrobials with known activity against Acinetobacter spp. Methods: The susceptibility of 246 carbapenem-resistant non-duplicate A. baumannii isolates to sulbactam/durlobactam, amikacin, colistin, imipenem/sulbactam/durlobactam, imipenem, meropenem, minocycline and sulbactam was tested using broth microdilution. Isolates were obtained from various body sites from patients in 37 countries and from six world regions between 2012 and 2016. Identification of carbapenem resistance mechanisms and assignment to A. baumannii clonal lineages was based onWGS. Results: Sulbactam/durlobactam showed excellent activity comparable to colistin but superior to amikacin, minocycline and sulbactam. The sulbactam/durlobactam MIC50/90 values were 1/4 and 2/4 mg/L and the colistin MIC50/90 values were 0.5 and 1 mg/L, respectively. Comparatively, amikacin, minocycline and sulbactam MIC50/90 values were 256/>= 512, 2/16 and 16/64 mg/L, respectively. Conclusions: Sulbactam/durlobactam had excellent in vitro potency against A. baumannii isolates, including those that were resistant to imipenem/meropenem, amikacin, minocycline and colistin, compared with other compounds. Sulbactam/durlobactamhas the potential to become a useful addition to the limited armamentarium of drugs that can be used to treat this problempathogen.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stefanik, DanutaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, Paul G.UNSPECIFIEDorcid.org/0000-0001-8677-9454UNSPECIFIED
Miller, AlitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kresken, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-320892
DOI: 10.1093/jac/dkaa208
Journal or Publication Title: J. Antimicrob. Chemother.
Volume: 75
Number: 9
Page Range: S. 2616 - 2622
Date: 2020
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PREVALENT OXA CARBAPENEMASES; SULBACTAM; GREECE; CLONE; PCRMultiple languages
Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32089

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