Kruis, Wolfgang and Schiff, Michael (2020). Combination Treatment with Antibiotics and Glucocorticosteroids for Severe Ischemic Colitis. Digestion, 101 (5). S. 500 - 506. BASEL: KARGER. ISSN 1421-9867

Full text not available from this repository.

Abstract

Background/Aims:Ischemic colitis (IC) is most common in the elderly and patients with multiple comorbidities. It carries significant mortality. As yet no evidence-based therapeutic management exists. Aim of the study was to test therapeutic efficacy of a combination of prednisolone and antibiotics.Methods:Prospective cohort study with retrospective analysis performed in a single teaching hospital in Germany. Consecutive patients with strict diagnostic criteria of severe IC, including colonoscopy, histology, and laboratory tests, were recruited. Main outcome measures were in-hospital mortality and number of operations counted within the hospital stay. Severity scores were calculated and biomarkers determined during the course of the hospital stay.Results:A total of 342 patients with an International Classification of Diseases of IC were identified. About 151 patients met the diagnostic criteria and a total of 44 patients fulfilled all inclusion and exclusion criteria of severe IC and constituted the group of patients eligible for analysis. Five out of 44 patients (11.4%) died (in-hospital mortality). Surgery was performed in 3 patients (6.8%), 2 patients survived. The hospital stay lasted 14.0 +/- 8.5 day and was significantly correlated with comorbidity (r(s) = 0.314,p= 0.038). No serious adverse events were observed.Conclusion:This is the first prospective study on therapeutic efficacy and safety in severe IC. The combination of intravenous antibiotics and intravenous prednisolone turned out to be safe and revealed promising efficacy. (c) 2019 S. Karger AG, Basel

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kruis, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiff, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-321227
DOI: 10.1159/000501515
Journal or Publication Title: Digestion
Volume: 101
Number: 5
Page Range: S. 500 - 506
Date: 2020
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1421-9867
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RISK-FACTORS; PATTERNS; OUTCOMES; PREDICTORS; MANAGEMENT; DISEASEMultiple languages
Gastroenterology & HepatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32122

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item