Kunas, Stefanie L., Hilbert, Kevin ORCID: 0000-0002-7986-4113, Yang, Yunbo, Richter, Jan ORCID: 0000-0002-7127-6990, Hamm, Alfons, Wittmann, Andre, Stroehle, Andreas, Pfleiderer, Bettina ORCID: 0000-0002-1238-6225, Herrmann, Martin J., Lang, Thomas, Lotze, Martin ORCID: 0000-0003-4519-4956, Deckert, Juergen, Arolt, Volker, Wittchen, Hans-Ulrich, Straube, Benjamin ORCID: 0000-0002-9837-0944, Kircher, Tilo, Gerlach, Alexander L. and Lueken, Ulrike (2020). The modulating impact of cigarette smoking on brain structure in panic disorder: a voxel-based morphometry study. Soc. Cogn. Affect. Neurosci., 15 (8). S. 849 - 860. OXFORD: OXFORD UNIV PRESS. ISSN 1749-5024

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Abstract

Cigarette smoking increases the likelihood of developing anxiety disorders, among them panic disorder (PD). While brain structures altered by smoking partly overlap with morphological changes identified in PD, the modulating impact of smoking as a potential confounder on structural alterations in PD has not yet been addressed. In total, 143 PD patients (71 smokers) and 178 healthy controls (62 smokers) participated in a multicenter magnetic resonance imaging (MRI) study. T1-weighted images were used to examine brain structural alterations using voxel-based morphometry in a priori defined regions of the defensive system network. PD was associated with gray matter volume reductions in the amygdala and hippocampus. This difference was driven by non-smokers and absent in smoking subjects. Bilateral amygdala volumes were reduced with increasing health burden (neither PD nor smoking > either PD or smoking > both PD and smoking). As smoking can narrow or diminish commonly observed structural abnormalities in PD, the effect of smoking should be considered in MRI studies focusing on patients with pathological forms of fear and anxiety. Future studies are needed to determine if smoking may increase the risk for subsequent psychopathology via brain functional or structural alterations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kunas, Stefanie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilbert, KevinUNSPECIFIEDorcid.org/0000-0002-7986-4113UNSPECIFIED
Yang, YunboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, JanUNSPECIFIEDorcid.org/0000-0002-7127-6990UNSPECIFIED
Hamm, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittmann, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stroehle, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfleiderer, BettinaUNSPECIFIEDorcid.org/0000-0002-1238-6225UNSPECIFIED
Herrmann, Martin J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lotze, MartinUNSPECIFIEDorcid.org/0000-0003-4519-4956UNSPECIFIED
Deckert, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arolt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Straube, BenjaminUNSPECIFIEDorcid.org/0000-0002-9837-0944UNSPECIFIED
Kircher, TiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, Alexander L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueken, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-324142
DOI: 10.1093/scan/nsaa103
Journal or Publication Title: Soc. Cogn. Affect. Neurosci.
Volume: 15
Number: 8
Page Range: S. 849 - 860
Date: 2020
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1749-5024
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GRAY-MATTER VOLUME; ANXIETY DISORDERS; NEUROANATOMICAL HYPOTHESIS; FUNCTIONAL CONNECTIVITY; TRYPTOPHAN-DEPLETION; DRUG-INTERACTIONS; MENTAL-ILLNESS; SMOKERS; NICOTINE; AMYGDALAMultiple languages
Neurosciences; Psychology; Psychology, ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32414

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