Universität zu Köln

Cwik, Jan Christopher ORCID: 0000-0002-2290-353X, Vahle, Nils, Woud, Marcella Lydia, Potthoff, Denise, Kessler, Henrik, Sartory, Gudrun and Seitz, Ruediger J. (2020). Reduced gray matter volume in the left prefrontal, occipital, and temporal regions as predictors for posttraumatic stress disorder: a voxel-based morphometric study. Eur. Arch. Psych. Clin. Neurosci., 270 (5). S. 577 - 589. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

The concept of acute stress disorder (ASD) was introduced as a diagnostic entity to improve the identification of traumatized people who are likely to develop posttraumatic stress disorder (PTSD). Neuroanatomical models suggest that changes in the prefrontal cortex, amygdala, and hippocampus play a role in the development of PTSD. Using voxel-based morphometry, this study aimed to investigate the predictive power of gray matter volume (GMV) alterations for developing PTSD. The GMVs of ASD patients (n = 21) were compared to those of PTSD patients (n = 17) and healthy controls (n = 18) in whole-brain and region-of-interest analyses. The GMV alterations seen in ASD patients shortly after the traumatic event (T1) were also correlated with PTSD symptom severity and symptom clusters 4 weeks later (T2). Compared with healthy controls, the ASD patients had significantly reduced GMV in the left visual cortex shortly after the traumatic event (T1) and in the left occipital and prefrontal regions 4 weeks later (T2); no significant differences in GMV were seen between the ASD and PTSD patients. Furthermore, a significant negative association was found between the GMV reduction in the left lateral temporal regions seen after the traumatic event (T1) and PTSD hyperarousal symptoms 4 weeks later (T2). Neither amygdala nor hippocampus alterations were predictive for the development of PTSD. These data suggest that gray matter deficiencies in the left hemispheric occipital and temporal regions in ASD patients may predict a liability for developing PTSD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cwik, Jan Christopher UNSPECIFIED orcid.org/0000-0002-2290-353X UNSPECIFIED Vahle, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Woud, Marcella Lydia UNSPECIFIED UNSPECIFIED UNSPECIFIED Potthoff, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Sartory, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Seitz, Ruediger J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325385
DOI:	10.1007/s00406-019-01011-2
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	270
Number:	5
Page Range:	S. 577 - 589
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STRUCTURAL BRAIN ABNORMALITIES; DUAL REPRESENTATION-THEORY; ANTERIOR CINGULATE CORTEX; VERBAL WORKING-MEMORY; HIPPOCAMPAL VOLUME; PSYCHOMETRIC PROPERTIES; PSYCHOLOGICAL TRAUMA; SYMPTOM PROVOCATION; CORTICAL THICKNESS; MIDLINE REGIONS Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32538