Universität zu Köln

Kasper, Philipp, Tacke, Frank, Steffen, Hans-Michael and Michels, Guido (2020). Hepatic dysfunction in sepsis. Med. Klin.-Intensivmed Notfallmed., 115 (7). S. 609 - 620. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2193-6226

Full text not available from this repository.

Abstract

Sepsis represents a life-threatening condition that frequently accompanies acute hepatic dysfunction. As a result of systemic inflammation, immune dysregulation, and microcirculatory derangements, different types of liver dysfunction can occur, such as hypoxic hepatitis, sepsis-associated cholestasis, or liver failure. A very serious and late sequela is secondary sclerosing cholangitis of the critically ill patient. Clinical management of sepsis-related liver dysfunction includes the rapid identification and treatment of the suspected underlying infection, hemodynamic stabilization to improve hepatic perfusion, and the optimization of oxygen delivery to the liver. Despite maximum efforts in supportive treatment, the outcome of patients with sepsis or septic shock and concomitant severe hepatic dysfunction remains very poor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kasper, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, Hans-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325627
DOI:	10.1007/s00063-020-00707-x
Journal or Publication Title:	Med. Klin.-Intensivmed Notfallmed.
Volume:	115
Number:	7
Page Range:	S. 609 - 620
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2193-6226
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRITICALLY-ILL PATIENTS; CHOLESTATIC LIVER; BILE; CHOLANGITIS; INJURY; ACID Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32562