Kasper, Philipp, Martin, Anna, Lang, Sonja, Kuetting, Fabian, Goeser, Tobias, Demir, Muenevver and Steffen, Hans-Michael ORCID: 0000-0001-6562-3549 . NAFLD and cardiovascular diseases: a clinical review. Clin. Res. Cardiol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in Western countries and affects approximately 25% of the adult population. Since NAFLD is frequently associated with further metabolic comorbidities such as obesity, type 2 diabetes mellitus, or dyslipidemia, it is generally considered as the hepatic manifestation of the metabolic syndrome. In addition to its potential to cause liver-related morbidity and mortality, NAFLD is also associated with subclinical and clinical cardiovascular disease (CVD). Growing evidence indicates that patients with NAFLD are at substantial risk for the development of hypertension, coronary heart disease, cardiomyopathy, and cardiac arrhythmias, which clinically result in increased cardiovascular morbidity and mortality. The natural history of NAFLD is variable and the vast majority of patients will not progress from simple steatosis to fibrosis and end stage liver disease. However, patients with progressive forms of NAFLD, including non-alcoholic steatohepatitis (NASH) and/or advanced fibrosis, as well as NAFLD patients with concomitant types 2 diabetes are at highest risk for CVD. This review describes the underlying pathophysiological mechanisms linking NAFLD and CVD, discusses the role of NAFLD as a metabolic dysfunction associated cardiovascular risk factor, and focuses on common cardiovascular manifestations in NAFLD patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kasper, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuetting, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeser, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demir, MuenevverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffen, Hans-MichaelUNSPECIFIEDorcid.org/0000-0001-6562-3549UNSPECIFIED
URN: urn:nbn:de:hbz:38-325968
DOI: 10.1007/s00392-020-01709-7
Journal or Publication Title: Clin. Res. Cardiol.
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1861-0692
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NONALCOHOLIC FATTY LIVER; EPICARDIAL ADIPOSE-TISSUE; LIFE-STYLE INTERVENTIONS; TYPE-2 DIABETES-MELLITUS; LONG-TERM OUTCOMES; INSULIN-RESISTANCE; FIBROSIS STAGE; BLOOD-PRESSURE; ENVIRONMENTAL STRESSORS; HISTOLOGIC FEATURESMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32596

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