Sonnabend, Kristina ORCID: 0000-0003-3064-0247, Brinker, Gerrit, Maintz, David, Bunck, Alexander C. and Weiss, Kilian (2021). Cerebrospinal fluid pulse wave velocity measurements: In vitro and in vivo evaluation of a novel multiband cine phase-contrast MRI sequence. Magn. Reson. Med., 85 (1). S. 211 - 223. HOBOKEN: WILEY. ISSN 1522-2594

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Abstract

Purpose Intracranial and intraspinal compliance are parameters of interest in the diagnosis and prediction of treatment outcome in patients with normal pressure hydrocephalus and other forms of communicating hydrocephalus. A noninvasive method to estimate the spinal cerebrospinal fluid (CSF) pulse wave velocity (PWV) as a measure of compliance was developed using a multiband cine phase-contrast MRI sequence and a foot-to-foot algorithm. Methods We used computational simulations to estimate the accuracy of the MRI acquisition and transit-time algorithm. In vitro measurements were performed to investigate the reproducibility and accuracy of the measurements under controlled conditions. In vivo measurements in 20 healthy subjects and 2 patients with normal pressure hydrocephalus were acquired to show the technical feasibility in a clinical setting. Results Simulations showed a mean deviation of the calculated CSF PWV of 3.41% +/- 2.68%. In vitro results were in line with theory, showing a square-root relation between PWV and transmural pressure and a good reproducibility with SDs of repeated measurements below 5%. Mean CSF PWV over all healthy subjects was 5.83 +/- 3.36 m/s. The CSF PWV measurements in the patients with normal pressure hydrocephalus were distinctly higher before CSF shunt surgery (33.80 +/- 6.75 m/s and 31.31 +/- 7.82 m/s), with a decrease 5 days after CSF shunt surgery (15.69 +/- 3.37 m/s). Conclusion This study evaluates the feasibility of CSF PWV measurements using a multiband cine phase-contrast MRI sequence. In vitro and in vivo measurements showed that this method is a potential tool for the noninvasive estimation of intraspinal compliance.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sonnabend, KristinaUNSPECIFIEDorcid.org/0000-0003-3064-0247UNSPECIFIED
Brinker, GerritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maintz, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bunck, Alexander C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, KilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-326037
DOI: 10.1002/mrm.28430
Journal or Publication Title: Magn. Reson. Med.
Volume: 85
Number: 1
Page Range: S. 211 - 223
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1522-2594
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTRACRANIAL COMPLIANCE; PRESSURE HYDROCEPHALUS; BLOOD-FLOW; RESPIRATION; RESISTANCE; DYNAMICS; OUTFLOWMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32603

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