Heger, Peter ORCID: 0000-0003-2583-2981, Zheng, Wen, Rottmann, Anna, Panfilio, Kristen A. and Wiehe, Thomas ORCID: 0000-0002-8932-2772 (2020). The genetic factors of bilaterian evolution. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

The Cambrian explosion was a unique animal radiation similar to 540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heger, PeterUNSPECIFIEDorcid.org/0000-0003-2583-2981UNSPECIFIED
Zheng, WenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottmann, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panfilio, Kristen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiehe, ThomasUNSPECIFIEDorcid.org/0000-0002-8932-2772UNSPECIFIED
URN: urn:nbn:de:hbz:38-326214
DOI: 10.7554/eLife.45530
Journal or Publication Title: eLife
Volume: 9
Date: 2020
Publisher: ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication: CAMBRIDGE
ISSN: 2050-084X
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LEUCINE-RICH REPEAT; NK-HOMEOBOX GENES; ORAL-ABORAL AXIS; TGF-BETA; PARAHOX GENES; SISTER GROUP; TRANSCRIPTION FACTORS; CONVERGENT EVOLUTION; MOLECULAR EVOLUTION; INSULATOR PROTEINSMultiple languages
BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/32621

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