Universität zu Köln

Duran, Ibrahim ORCID: 0000-0003-4044-8822, Martakis, Kyriakos, Stark, Christina, Schafmeyer, Leonie, Rehberg, Mirko and Schoenau, Eckhard (2020). Effect of an interval rehabilitation program with home-based, vibration-assisted training on the development of muscle and bone in children with cerebral palsy an observational study. J. Pediatr. Endocrinol. Metab., 33 (8). S. 1083 - 1093. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2191-0251

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Abstract

Objectives: In children with cerebral palsy (CP), the most common cause of physical impairment in childhood, less muscle and bone growth has been reported, when compared with typically developing children. The aim of this study was to evaluate the effect of an intensive rehabilitation program including physiotherapy in combination with 6 months of home-based, vibration-assisted training on muscle and bone growth in children with CP. Methods: We included children with CP, who participated in a rehabilitation program utilizing whole-body vibration (WBV). Muscle mass was quantified by appendicular lean mass index (App-LMI) and bone mass by total-body-lesshead bone mineral content (TBLH-BMC) assessed by Dual-energy X-ray absorptiometry (DXA) at the beginning of rehabilitation and one year later. To assess the functional muscle-bone unit, the relation of TBLH-BMC to TBLH lean body mass (TBLH-LBM) was used. Results: The study population included 128 children (52 females, mean age 11.9 +/- 2.7). App-LMI assessed in kg/m2 increased significantly after rehabilitation. The age-adjusted Z-score for App-LMI showed no significant change. TBLH-BMC assessed in gram increased significantly. The Z-scores for TBLH-BMC decreased lesser than expected by the evaluation of the cross-sectional data at the beginning of rehabilitation. The parameter TBLH-BMC/TBLH-LBM did not change relevantly after 12 months. Conclusions: Muscle growth and to a lesser extent bone growth could be increased in children with CP. The intensive rehabilitation program including WBV seemed to have no direct effect on the bone, but the observed anabolic effect on the bone, may only been mediated through the muscle.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duran, Ibrahim UNSPECIFIED orcid.org/0000-0003-4044-8822 UNSPECIFIED Martakis, Kyriakos UNSPECIFIED UNSPECIFIED UNSPECIFIED Stark, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schafmeyer, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, Mirko UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-327356
DOI:	10.1515/jpem-2020-0080
Journal or Publication Title:	J. Pediatr. Endocrinol. Metab.
Volume:	33
Number:	8
Page Range:	S. 1083 - 1093
Date:	2020
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2191-0251
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROSS MOTOR FUNCTION; HIGH-FREQUENCY; BODY-COMPOSITION; ADOLESCENTS; DENSITY; GROWTH; UNIT Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32735