Universität zu Köln

Barani, Hossein, Khorashadizadeh, Mohsen, Haseloer, Alexander ORCID: 0000-0003-0480-7568 and Klein, Axel ORCID: 0000-0003-0093-9619 (2020). Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers. Polymers, 12 (7). BASEL: MDPI. ISSN 2073-4360

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Abstract

Mats of polyvinyl alcohol (PVA) core-shell nanofibers were produced using coaxial electrospinning in the presence of a thiosemicarbazone (TSC)N4-(S)-1-phenylethyl)-2-(pyridin-2-yl-ethylidene)hydrazine-1-carbothioamide (HapyTSCmB). Monolithic fibers with 0% or 5% TSC and core-shell fibers with 10% TSC in the spinning solution were studied to compare stability and release rates. SEM showed the formation of uniform, bead-free, cylindrical, and smooth fibers. NMR spectroscopy and thermal analysis (TG/DTA) gave proof for the chemical integrity of the TSC in the fiber mats after the electrospinning process. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy showed no TSC on the surface of the PVA/TSC-PVA fibers confirming the core-shell character. The TSC release profiles of the fibers as studied using UV-vis absorption spectroscopy showed a slower release from the PVA/TSC-PVA core-shell structure compared with the monolithic PVA/TSC fibers as well as lower cumulative release percentage (17%). Out of several release models, the Korsmeyer-Peppas model gave the best fit to the experimental data. The main release phase can be described with a Fick-type diffusion mechanism. Antibacterial properties were tested against the Gram-positiveStaphylococcus aureusbacterium and gave a minimal inhibitory concentration of 12.5 mu g/mL. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT)-based cytotoxicity experiments showed that the cell viability of fibroblast at different contents of TSC was slightly decreased from 1.5% up to 3.5% when compared to control cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barani, Hossein UNSPECIFIED UNSPECIFIED UNSPECIFIED Khorashadizadeh, Mohsen UNSPECIFIED UNSPECIFIED UNSPECIFIED Haseloer, Alexander UNSPECIFIED orcid.org/0000-0003-0480-7568 UNSPECIFIED Klein, Axel UNSPECIFIED orcid.org/0000-0003-0093-9619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-327434
DOI:	10.3390/polym12071488
Journal or Publication Title:	Polymers
Volume:	12
Number:	7
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4360
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HERPES-SIMPLEX-VIRUS; DRUG-DELIVERY; 2-ACETYLPYRIDINE THIOSEMICARBAZONES; METAL-COMPLEXES; DERIVATIVES; ANTIBACTERIAL; PARAMETERS; FIBERS; INHIBITORS; MORPHOLOGY Multiple languages Polymer Science Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32743