Universität zu Köln

Gerarduzzi, Casimiro, Hartmann, Ursula, Leask, Andrew and Drobetsky, Elliot (2020). The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment. Cancer Res., 80 (13). S. 2705 - 2718. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

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Abstract

The extracellular matrix (ECM) surrounding cells is indispensable for regulating their behavior. The dynamics of ECM signaling are tightly controlled throughout growth and development. During tissue remodeling, matricellular proteins (MCP) are secreted into the ECM. These factors do not serve classical structural roles, but rather regulate matrix proteins and cell-matrix interactions to influence normal cellular functions. In the tumor microenvironment, it is becoming increasingly clear that aberrantly expressed MCPs can support multiple hallmarks of carcinogenesis by interacting with various cellular components that are coupled to an array of downstream signals. Moreover, MCPs also reorganize the biomechanical properties of the ECM to accommodate metastasis and tumor colonization. This realization is stimulating new research on MCPs as reliable and accessible biomarkers in cancer, as well as effective and selective therapeutic targets.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gerarduzzi, Casimiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Leask, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Drobetsky, Elliot UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-328007
DOI:	10.1158/0008-5472.CAN-18-2098
Journal or Publication Title:	Cancer Res.
Volume:	80
Number:	13
Page Range:	S. 2705 - 2718
Date:	2020
Publisher:	AMER ASSOC CANCER RESEARCH
Place of Publication:	PHILADELPHIA
ISSN:	1538-7445
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TISSUE GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; LINKED GLYCOPROTEINS SIBLINGS; SQUAMOUS-CELL CARCINOMA; SPARC-NULL MICE; TENASCIN-C; BREAST-CANCER; EXTRACELLULAR-MATRIX; GLA PROTEIN; BONE SIALOPROTEIN Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32800