Bikdeli, Behnood, Madhavan, Mahesh V., Gupta, Aakriti, Jimenez, David, Burton, John R., Nigoghossian, Caroline Der, Chuich, Taylor, Nouri, Shayan Nabavi, Dreyfus, Isaac, Driggin, Elissa, Sethi, Sanjum ORCID: 0000-0002-3438-7034, Sehgal, Kartik ORCID: 0000-0003-4391-6943, Chatterjee, Saurav, Ageno, Walter, Madjid, Mohammad, Guo, Yutao, Tang, Liang V., Hu, Yu, Bertoletti, Laurent, Giri, Jay, Cushman, Mary, Quere, Isabelle, Dimakakos, Evangelos P., Gibson, C. Michael, Lippi, Giuseppe, Favaloro, Emmanuel J., Fareed, Jawed, Tafur, Alfonso J., Francese, Dominic P., Batra, Jaya, Falanga, Anna, Clerkin, Kevin J., Uriel, Nir, Kirtane, Ajay, McLintock, Claire, Hunt, Beverley J., Spyropoulos, Alex C., Barnes, Geoffrey D., Eikelboom, John W., Weinberg, Ido, Schulman, Sam, Carrier, Marc, Piazza, Gregory, Beckman, Joshua A., Leon, Martin B., Stone, Gregg W., Rosenkranz, Stephan, Goldhaber, Samuel Z., Parikh, Sahil A., Monreal, Manuel, Krumholz, Harlan M., Konstantinides, Stavros V., Weitz, Jeffrey I. and Lip, Gregory Y. H. (2020). Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research. Thromb. Haemost., 120 (7). S. 1004 - 1025. STUTTGART: GEORG THIEME VERLAG KG. ISSN 2567-689X

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Abstract

Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct antithrombotic effects, other mechanisms of action, including anti-inflammatory or antiviral effects, have been postulated. Based on survey results from this group of authors, we suggest research priorities for specific agents and subgroups of patients with COVID-19. Further, we review other agents, including immunomodulators, that may have antithrombotic properties. It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bikdeli, BehnoodUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Madhavan, Mahesh V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gupta, AakritiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimenez, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burton, John R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nigoghossian, Caroline DerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chuich, TaylorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nouri, Shayan NabaviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreyfus, IsaacUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Driggin, ElissaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sethi, SanjumUNSPECIFIEDorcid.org/0000-0002-3438-7034UNSPECIFIED
Sehgal, KartikUNSPECIFIEDorcid.org/0000-0003-4391-6943UNSPECIFIED
Chatterjee, SauravUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ageno, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Madjid, MohammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guo, YutaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tang, Liang V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hu, YuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertoletti, LaurentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giri, JayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cushman, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quere, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dimakakos, Evangelos P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibson, C. MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lippi, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Favaloro, Emmanuel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fareed, JawedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tafur, Alfonso J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Francese, Dominic P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Batra, JayaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falanga, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clerkin, Kevin J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uriel, NirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirtane, AjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McLintock, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunt, Beverley J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spyropoulos, Alex C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barnes, Geoffrey D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eikelboom, John W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinberg, IdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulman, SamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrier, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piazza, GregoryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckman, Joshua A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leon, Martin B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stone, Gregg W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenkranz, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldhaber, Samuel Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parikh, Sahil A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monreal, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumholz, Harlan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konstantinides, Stavros V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weitz, Jeffrey I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lip, Gregory Y. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-328077
DOI: 10.1055/s-0040-1713152
Journal or Publication Title: Thromb. Haemost.
Volume: 120
Number: 7
Page Range: S. 1004 - 1025
Date: 2020
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 2567-689X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RESPIRATORY-DISTRESS-SYNDROME; CRITICALLY-ILL PATIENTS; DISSEMINATED INTRAVASCULAR COAGULATION; HEPARIN-INDUCED THROMBOCYTOPENIA; ACUTE MYOCARDIAL-INFARCTION; MOLECULAR-WEIGHT HEPARIN; ANTITHROMBIN-III; INTRACRANIAL HEMORRHAGE; PULMONARY COAGULOPATHY; UNFRACTIONATED HEPARINMultiple languages
Hematology; Peripheral Vascular DiseaseMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32807

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