Universität zu Köln

Sharma, Amit ORCID: 0000-0002-2216-5389, Weber, Daniela, Raupbach, Jana ORCID: 0000-0002-7404-0449, Dakal, Tikam Chand, Fliessbach, Klaus, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Grune, Tilman and Wuellner, Ullrich (2020). Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease. Redox Biol., 34. AMSTERDAM: ELSEVIER. ISSN 2213-2317

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Abstract

Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident, that advanced glycation end products (AGEs) trigger the accumulation of such modified proteins, which eventually contributes to pathological aspect of NDDs. Increased levels of AGEs are found in amyloid plaques in AD brains and in both advanced and early PD (incidental Lewy body disease). The molecular mechanisms by which AGE dependent modifications may modulate the susceptibility towards NDDs, however, remain enigmatic and it is unclear, whether AGEs may serve as biomarker of NDD. In the present study, we examined AGEs (CML: Carboxymethyllysine and CEL: Carboxyethyllysine), markers of oxidative stress and micronutrients in the plasma of PD and AD patients and controls. As compared to healthy controls, AD females displayed lower levels of CEL while higher levels of CML were found in AD and PD patients. A somewhat similar pattern was observed for protein carbonyls (PC), revealing lower values exclusively in AD females, whereas AD males displayed significantly higher values compared to healthy controls and PD. Sex-specific differences were also observed for other relevant markers such as malondialdehyde, 3-nitrotyrosine, gamma-tocopherols, retinol, plasma proteins and alpha-carotene, while alpha-tocopherols, beta-carotene, lutein/zeaxanthin, beta-cryptoxanthin and lycopene showed no relevant association. Taken together, our study suggests yet unappreciated differences of the distribution of AGEs among the sexes in NDD. We therefore suggest to make a clear distinction between sexes when analyzing oxidative (AGEs)-related stress and carbonyl-related stress and vitamins.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sharma, Amit UNSPECIFIED orcid.org/0000-0002-2216-5389 UNSPECIFIED Weber, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Raupbach, Jana UNSPECIFIED orcid.org/0000-0002-7404-0449 UNSPECIFIED Dakal, Tikam Chand UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Grune, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuellner, Ullrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-328121
DOI:	10.1016/j.redox.2020.101546
Journal or Publication Title:	Redox Biol.
Volume:	34
Date:	2020
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2213-2317
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; OXIDATIVE STRESS MARKERS; BRAIN; AGGREGATION; INCREASE; DAMAGE; BLOOD Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32812