Dafsari, Haidar S., Ray-Chaudhuri, K., Ashkan, Keyoumars, Sachse, Lena, Mahlstedt, Picabo, Silverdale, Monty, Rizos, Alexandra, Strack, Marian, Jost, Stefanie T., Reker, Paul, Samuel, Michael, Visser-Vandewalle, Veerle, Evans, Julian, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo, Timmermann, Lars, Ray-Chaudhuri, Kallol, Ray-Chaudhuri, Kallol, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo, Schrag, Anette, Weintraub, Daniel, Barone, Paolo, Brooks, David J., Brown, Richard G., Jenner, Peter, Jeon, B., Lyons, Kelly, Pavese, Nicola, Politis, Marios, Postuma, Ronald B., Schapira, Anthony ORCID: 0000-0002-3018-3966, Stocchi, Fabrizio, Timmermann, Lars, Tsuboi, Yoshio, Rizos, Alexandra and Sauerbier, Anna ORCID: 0000-0003-0966-5933 (2020). Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson's disease. J. Neurol., 267 (6). S. 1830 - 1842. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

Background Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. Methods In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Results Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up. Conclusions In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ray-Chaudhuri, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ashkan, KeyoumarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachse, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahlstedt, PicaboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverdale, MontyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rizos, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strack, MarianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jost, Stefanie T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reker, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samuel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Martinez-Martin, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ray-Chaudhuri, KallolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ray-Chaudhuri, KallolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Martinez-Martin, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrag, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weintraub, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barone, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brooks, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brown, Richard G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenner, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeon, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lyons, KellyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavese, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Politis, MariosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Postuma, Ronald B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schapira, AnthonyUNSPECIFIEDorcid.org/0000-0002-3018-3966UNSPECIFIED
Stocchi, FabrizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsuboi, YoshioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rizos, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauerbier, AnnaUNSPECIFIEDorcid.org/0000-0003-0966-5933UNSPECIFIED
URN: urn:nbn:de:hbz:38-331895
DOI: 10.1007/s00415-020-09743-1
Journal or Publication Title: J. Neurol.
Volume: 267
Number: 6
Page Range: S. 1830 - 1842
Date: 2020
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-1459
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; OF-LIFE; NUCLEUS STIMULATION; REM-SLEEP; SCALE; ARCHITECTURE; IMPROVEMENT; TRIAL; PDMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33189

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