Universität zu Köln

Rehberg, Mirko, Azim, Manuela, Martakis, Kyriakos, Winzenrieth, Renaud, Hoyer-Kuhn, Heike, Schoenau, Eckhard, Semler, Oliver and Duran, Ibrahim ORCID: 0000-0003-4044-8822 (2020). Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients with Cerebral Palsy. J. Bone Miner. Res., 35 (9). S. 1685 - 1695. HOBOKEN: WILEY. ISSN 1523-4681

Full text not available from this repository.

Abstract

Bone strength and fracture risk do not only depend on bone density, but also on bone structure. The trabecular bone score (TBS) evaluates homogeneity of bone microarchitecture indirectly by measuring gray-level variations of two-dimensional (2D) DXA images. Although TBS is well-established for adults, there have been only few publications in pediatrics. In this monocentric retrospective analysis, we investigated TBS in children and adolescents with cerebral palsy (CP), a patient group vulnerable to low bone mineral mass due to impaired mobility. The influence of different parameters on TBS and areal BMD (aBMD) were evaluated, as well as the relationship between TBS and aBMD. We compared TBS values of our study population to a reference population. A total of 472 lumbar spine-dual-energy X-ray absorptiometry (LS-DXA) scans of children and adolescents with CP (205 female), aged between 4 and 18 years, were analyzed. The DXA-scans were part of the routine examination. The children had no records of fractures or specific bone diseases. Our study population with CP had similar TBS as the reference population. TBS did not increase with age until an inflection point at 10 years in females, and 12 years in males. Girls had significantly higher TBS than boys (p = .049) and pubertal girls aged 8 to 13 years had significantly higher TBS than prepubertal girls (p = .009). TBS standard deviation score for age (SDS-TBS) and aBMD Z-scores correlated weakly (p < .001; R = 0.276 [males], R = 0.284 [females]). Other than for aBMD Z-scores, SDS-TBS was not influenced by age-adjusted height Z-scores and there was no significant difference in SDS-TBS when grouped by mobility levels, using the Gross Motor Function Classification System (GMFCS). Our results indicate that children with CP have a similar homogeneous distribution of trabecular microarchitecture as controls. Puberty initiation appears to be essential for increase of TBS with age and for sex differences. TBS seems less influenced by body composition, height, and mobility than aBMD. (c) 2020 American Society for Bone and Mineral Research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rehberg, Mirko UNSPECIFIED UNSPECIFIED UNSPECIFIED Azim, Manuela UNSPECIFIED UNSPECIFIED UNSPECIFIED Martakis, Kyriakos UNSPECIFIED UNSPECIFIED UNSPECIFIED Winzenrieth, Renaud UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyer-Kuhn, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Duran, Ibrahim UNSPECIFIED orcid.org/0000-0003-4044-8822 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-332207
DOI:	10.1002/jbmr.4047
Journal or Publication Title:	J. Bone Miner. Res.
Volume:	35
Number:	9
Page Range:	S. 1685 - 1695
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1523-4681
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MINERAL DENSITY; BODY-COMPOSITION; CHILDREN; TBS; OSTEOPOROSIS; ADOLESCENTS; FRACTURES; RISK; PARAMETERS; STRENGTH Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33220