Berking, Ann-Cathrine ORCID: 0000-0003-2658-4211, Thiel, Christiane, Schiele, Miriam A., Baumann, Christian, Kalisch, Raffael, Notzen, Swantje, Zwanzger, Peter, Pane-Farre, Christiane A., Hamm, Alfons, Alpers, Georg W., Fydrich, Thomas, Fehm, Lydia, Gerlach, Alexander L., Straube, Benjamin ORCID: 0000-0002-9837-0944, Kircher, Tilo, Rief, Winfried, Plag, Jens, Stroehle, Andreas, Lang, Thomas, Wittchen, Hans-Ulrich ORCID: 0000-0002-6311-7711, Arolt, Volker, Romanos, Marcel ORCID: 0000-0001-7628-8299, Pauli, Paul, Reif, Andreas, Deckert, Juergen, Domschke, Katharina and Weber, Heike (2020). An investigation of genetic variability of DNA methyltransferasesDNMT3Aand3Bdoes not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes. J. Neural Transm., 127 (11). S. 1527 - 1538. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation-DNA methyltransferases (DNMTs)-has yet to be investigated. In an effort to investigate DNMT genotype-specific effects on dimensional anxiety traits in addition to the categorical phenotype of panic disorder, 506 panic disorder patients and 3112 healthy participants were assessed for anxiety related cognition [Agoraphobic Cognitions Questionnaire (ACQ)], anxiety sensitivity [Anxiety Sensitivity Index (ASI)] as well as pathological worry [Penn State Worry Questionnaire (PSWQ)] and genotyped for five single nucleotide polymorphisms (SNPs) in theDNMT3A(rs11683424, rs1465764, rs1465825) andDNMT3B(rs2424932, rs4911259) genes, which have previously been found associated with clinical and trait-related phenotypes. There was no association with the categorical phenotype panic disorder. However, a significant association was discerned betweenDNMT3Ars1465764 and PSWQ scores in healthy participants, with the minor allele conveying a protective effect. In addition, a marginally significant association between questionnaire scores (PSWQ, ASI) in healthy participants andDNMT3Brs2424932 was detected, again with the minor allele conveying a protective effect. The present results suggest a possible minor role ofDNMT3AandDNMT3Bgene variation in conveying resilience towards anxiety disorders. As the observed associations indicated a protective effect of two SNPs particularly with pathological worry, future studies are proposed to explore these variants in generalized anxiety disorder rather than panic disorder.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Berking, Ann-CathrineUNSPECIFIEDorcid.org/0000-0003-2658-4211UNSPECIFIED
Thiel, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiele, Miriam A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalisch, RaffaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Notzen, SwantjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zwanzger, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pane-Farre, Christiane A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamm, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpers, Georg W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fydrich, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, LydiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, Alexander L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Straube, BenjaminUNSPECIFIEDorcid.org/0000-0002-9837-0944UNSPECIFIED
Kircher, TiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rief, WinfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plag, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stroehle, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDorcid.org/0000-0002-6311-7711UNSPECIFIED
Arolt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romanos, MarcelUNSPECIFIEDorcid.org/0000-0001-7628-8299UNSPECIFIED
Pauli, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reif, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deckert, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domschke, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-332609
DOI: 10.1007/s00702-020-02206-x
Journal or Publication Title: J. Neural Transm.
Volume: 127
Number: 11
Page Range: S. 1527 - 1538
Date: 2020
Publisher: SPRINGER WIEN
Place of Publication: WIEN
ISSN: 1435-1463
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EPIDEMIOLOGY; DNMT3A; ASSOCIATION; METHYLATION; DEPRESSION; BEHAVIOR; ATTACKSMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33260

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