Universität zu Köln

Strizek, B., Gottschalk, I, Recker, F., Weber, E., Floeck, A., Gembruch, U., Geipel, A. and Berg, C. (2020). Vesicoamniotic shunting for fetal megacystis in the first trimester with a Somatex(R) intrauterine shunt. Arch. Gynecol. Obstet., 302 (1). S. 133 - 141. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

Purpose The objective was to evaluate the feasibility of vesicoamniotic shunting (VAS) in the first trimester with the Somatex(R) intrauterine shunt and report on complications and neonatal outcome. Methods Retrospective cohort study of all VAS before 14 weeks at two tertiary fetal medicine centres from 2015 to 2018 using a Somatex(R) intrauterine shunt. All patients with a first trimester diagnosis of megacystis in male fetuses with a longitudinal bladder diameter of at least 15 mm were offered VAS. All patients that opted for VAS after counselling by prenatal medicine specialists, neonatologists and pediatric nephrologists were included in the study. Charts were reviewed for complications, obstetric and neonatal outcomes. Results Ten VAS were performed during the study period in male fetuses at a median GA of 13.3 (12.6-13.9) weeks. There were two terminations of pregnancy (TOP) due to additional malformations and one IUFD. Overall there were four shunt dislocations (40%); three of those between 25-30 weeks GA. Seven neonates were born alive at a median GA of 35.1 weeks (31.0-38.9). There was one neonatal death due to pulmonary hypoplasia. Neonatal kidney function was normal in the six neonates surviving the neonatal period. After exclusion of TOP, perinatal survival was 75%, and 85.7% if only live-born children were considered. Conclusion VAS in the first trimester is feasible with the Somatex(R) Intrauterine shunt with low fetal and maternal complication rates. Neonatal survival rates are high due to a reduction in pulmonary hypoplasia and the rate of renal failure at birth is very low. VAS can be safely offered from the late first trimester using the Somatex(R) intrauterine shunt.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Strizek, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottschalk, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Recker, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Floeck, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-333058
DOI:	10.1007/s00404-020-05598-z
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	302
Number:	1
Page Range:	S. 133 - 141
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language URINARY-TRACT OBSTRUCTION; IN-UTERO PRESERVE; URETHRAL OBSTRUCTION; INTERVENTION; FETUSES; GESTATION; 1ST-HALF; INUTERO; KIDNEYS; LAMBS Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33305