Universität zu Köln

d'Hargues, Y., Prinz, J., Goedel, P., Shimabukuro-Vornhagen, A., Kochanek, M. and Boell, B. (2020). y Diagnosis and treatment of immune-related adverse events during checkpoint inhibitor therapy in intensive care medicine. Med. Klin.-Intensivmed Notfallmed., 115 (4). S. 281 - 286. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2193-6226

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Abstract

Background Due to the use of checkpoint inhibitors, intensive care units will be confronted with an increasing number of patients with immune-related adverse events. A broad spectrum of symptoms and potentially lethal consequences make diagnosis and treatment challenging. Objectives Diagnosis and treatment of immune-related adverse events in the treatment with checkpoint inhibitors with a special focus on intensive care units. Materials and methods Review of current publications about incidence, symptoms and treatment of adverse events after the use of checkpoint inhibitors relevant for intensive care medicine. Results Immune-related adverse events during therapy with checkpoint inhibitors are difficult to diagnose and present with various symptoms. Severe complications can often successfully be treated with early therapy. Conclusions The early treatment of immune-related adverse events according to their severity is needed to prevent a potentially life-threatening course.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code d'Hargues, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prinz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goedel, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boell, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335634
DOI:	10.1007/s00063-018-0521-z
Journal or Publication Title:	Med. Klin.-Intensivmed Notfallmed.
Volume:	115
Number:	4
Page Range:	S. 281 - 286
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2193-6226
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MELANOMA; PEMBROLIZUMAB; IMMUNOTHERAPY; PNEUMONITIS; MANAGEMENT; IPILIMUMAB; NIVOLUMAB Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33563