Universität zu Köln

Brochhausen, Christoph, Grevenstein, David, Mamilos, Andreas, Babel, Maximilian and Eysel, Peer (2020). Histological diagnostics in joint pathology due to increasing regenerative therapeutic strategies - special consideration for cartilage damage. Pathologe, 41 (3). S. 271 - 280. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1963

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Abstract

Orthopedic and trauma surgery are currently confronted with significant changes in their interventional and therapeutic strategies, especially in knee surgery. Minimally invasive and reconstructive techniques lead not only to modifications of the repertoire of interventional methods but also of the indications and questions for histopathological diagnostics. The classical problems in knee surgery remain important issues, which are traumatic, degenerative, and infectious lesions. In addition, questions regarding regeneration and integration of cell-material constructs will become more and more important in the future. Furthermore, questions regarding the regenerative potential of an implantation site for such constructs and the morphological quality of harvested tissue for the in vitro cell expansion of autologous cells are becoming increasingly important. The autologous chondrocyte transplantation is a good example of the relevance of the histopathological re-evaluation of the regenerated tissue for a better understanding of the pathophysiology of reconstructive therapies. It becomes clear that for specific aims based on reconstructive therapies, new scoring systems should be established for the histopathological routine diagnostic service. Furthermore, there is need for the definition of further histopathological criteria, which will help to optimize the differential application of reconstructive strategies via tissue engineering. The present report gives a short overview of the modifying requirements on the histopathological diagnostics in specimens from knee-surgery but does not claim to be exhaustive.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brochhausen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Grevenstein, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Mamilos, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Babel, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, Peer UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335864
DOI:	10.1007/s00292-020-00768-x
Journal or Publication Title:	Pathologe
Volume:	41
Number:	3
Page Range:	S. 271 - 280
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1963
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ARTICULAR-CARTILAGE; TISSUE; OSTEOARTHRITIS; HISTOPATHOLOGY; DEGENERATION; INTEGRITY; MENISCUS; SYSTEM; KNEE Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33586