Universität zu Köln

Laukamp, Kai Roman ORCID: 0000-0002-5600-5914, Lennartz, Simon, Hashmi, Ahmad, Obmann, Markus ORCID: 0000-0001-6586-0034, Ho, Vivian, Hokamp, Nils Grosse, Graner, Frank Philipp, Gilkeson, Robert, Persigehl, Thorsten, Gupta, Amit and Ramaiya, Nikhil (2020). Iodine accumulation of the liver in patients treated with amiodarone can be unmasked using material decomposition from multiphase spectral-detector CT. Sci Rep, 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Amiodarone accumulates in the liver, where it increases x-ray attenuation due to its iodine content. We evaluated liver attenuation in patients treated and not treated with amiodarone using true-non-contrast (TNC) and virtual-non-contrast (VNC) images acquired with spectral-detector-CT (SDCT). 142 patients, of which 21 have been treated with amiodarone, receiving SDCT-examinations (unenhanced-chest CT [TNC], CT-angiography of chest and abdomen [CTA-Chest, CTA-Abdomen]) were included. TNC, CTA-Chest, CTA-Abdomen, and corresponding VNC-images (VNC-Chest, VNC-Abdomen) were reconstructed. Liver-attenuation-index (LAI) was calculated as difference between liver- and spleen-attenuation. Liver-attenuation and LAI derived from TNC-images of patients receiving amiodarone were higher. Contrary to TNC, liver-attenuation and LAI were not higher in amiodarone patients in VNC-Chest and in VNC-Abdomen. To verify these initial results, a phantom scan was performed and an additional patient cohort included, both confirming that VNC is viable of accurately subtracting iodine of hepatic amiodarone-deposits. This might help to monitor liver-attenuation more accurately and thereby detect liver steatosis as a sign of liver damage earlier as well as to verify amiodarone accumulation in the liver.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laukamp, Kai Roman UNSPECIFIED orcid.org/0000-0002-5600-5914 UNSPECIFIED Lennartz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Hashmi, Ahmad UNSPECIFIED UNSPECIFIED UNSPECIFIED Obmann, Markus UNSPECIFIED orcid.org/0000-0001-6586-0034 UNSPECIFIED Ho, Vivian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Graner, Frank Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Gilkeson, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Gupta, Amit UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramaiya, Nikhil UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-336509
DOI:	10.1038/s41598-020-64002-7
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRTUAL NON-CONTRAST; MACROVESICULAR HEPATIC STEATOSIS; ATTENUATION VALUES; UNENHANCED CT; FAT-CONTENT; TOMOGRAPHY; PHOSPHOLIPIDOSIS; DIAGNOSIS; PHARMACOKINETICS; PHARMACOLOGY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33650