Universität zu Köln

Michely, Jochen, Viswanathan, Shivakumar ORCID: 0000-0002-7513-3778, Hauser, Tobias U. ORCID: 0000-0002-7997-8137, Delker, Laura, Dolan, Raymond J. and Grefkes, Christian (2020). The role of dopamine in dynamic effort-reward integration. Neuropsychopharmacology, 45 (9). S. 1448 - 1454. LONDON: NATURE PUBLISHING GROUP. ISSN 1740-634X

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Abstract

When deciding to act, the neurotransmitter dopamine is implicated in a valuation of prospective effort and reward. However, its role in dynamic effort-reward integration during action, a process central to everyday behaviour, remains unclear. In a placebo-controlled, within-subject, study, we probed the impact of increasing brain dopamine levels (150 mg of levodopa) and blocking dopamine receptors (1.5 mg of haloperidol) in the context of a novel dynamic effort task in healthy human subjects. We show that modulating homoeostatic dopamine balance distinctly alters implicit and explicit effort allocation as a function of instantaneous reward. Pharmacologically boosting dopamine enhanced motor vigour, reflected in an implicit increase in effort allocation for high rewards. Conversely, pharmacological blockade of dopamine attenuated sensitivity to differences in reward context, reflected in reduced strategic effort discounting. These findings implicate dopamine in an integration of momentary physical experience and instantaneous reward, suggesting a key role of dopamine in acting to maximise reward on the fly.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Michely, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Viswanathan, Shivakumar UNSPECIFIED orcid.org/0000-0002-7513-3778 UNSPECIFIED Hauser, Tobias U. UNSPECIFIED orcid.org/0000-0002-7997-8137 UNSPECIFIED Delker, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolan, Raymond J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-337408
DOI:	10.1038/s41386-020-0669-0
Journal or Publication Title:	Neuropsychopharmacology
Volume:	45
Number:	9
Page Range:	S. 1448 - 1454
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1740-634X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOTIVATIONAL FUNCTIONS; MECHANISMS; WILLINGNESS; DEFICITS; MOTOR Multiple languages Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33740