Universität zu Köln

Schloesser, Madita, Kartashev, Vladimir V., Mikkola, Visa H., Shemshura, Andrey ORCID: 0000-0003-1637-4229, Saukhat, Sergey, Kolpakov, Dmitriy, Suladze, Alexandr, Tverdokhlebova, Tatiana, Hutt, Katharina, Heger, Eva, Knops, Elena ORCID: 0000-0001-7398-3026, Boehm, Michael, Di Cristanziano, Veronica, Kaiser, Rolf, Sonnerborg, Anders, Zazzi, Maurizio ORCID: 0000-0002-0344-6281, Bobkova, Marina ORCID: 0000-0001-5481-8957 and Sierra, Saleta (2020). HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia. Viruses-Basel, 12 (4). BASEL: MDPI. ISSN 1999-4915

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Abstract

Russia has one of the largest and fastest growing HIV epidemics. However, epidemiological data are scarce. Sub-subtype A6 is most prevalent in Russia but its identification is challenging. We analysed protease/reverse transcriptase-, integrase-sequences, and epidemiological data from 303 patients to develop a methodology for the systematisation of A6 identification and to describe the HIV epidemiology in the Russian Southern Federal District. Drug consumption (32.0%) and heterosexual contact (27.1%) were the major reported transmission risks. This study successfully established the settings for systematic identification of A6 samples. Low frequency of subtype B (3.3%) and large prevalence of sub-subtype A6 (69.6%) and subtype G (23.4%) were detected. Transmitted PI(8.8%) and NRTI-resistance (6.4%) were detected in therapy-naive patients. In therapy-experienced patients, 17.3% of the isolates showed resistance to PIs, 50.0% to NRTI, 39.2% to NNRTIs, and 9.5% to INSTIs. Multiresistance was identified in 52 isolates, 40 corresponding to two-class resistance and seven to three-class resistance. Two resistance-associated-mutations significantly associated to sub-subtype A6 samples: A62VRT and G190SRT. This study establishes the conditions for a systematic annotation of sub-subtype A6 to normalise epidemiological studies. Accurate knowledge on South Russian epidemiology will allow for the development of efficient regional frameworks for HIV-1 infection management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schloesser, Madita UNSPECIFIED UNSPECIFIED UNSPECIFIED Kartashev, Vladimir V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mikkola, Visa H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shemshura, Andrey UNSPECIFIED orcid.org/0000-0003-1637-4229 UNSPECIFIED Saukhat, Sergey UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolpakov, Dmitriy UNSPECIFIED UNSPECIFIED UNSPECIFIED Suladze, Alexandr UNSPECIFIED UNSPECIFIED UNSPECIFIED Tverdokhlebova, Tatiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Hutt, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Knops, Elena UNSPECIFIED orcid.org/0000-0001-7398-3026 UNSPECIFIED Boehm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Sonnerborg, Anders UNSPECIFIED UNSPECIFIED UNSPECIFIED Zazzi, Maurizio UNSPECIFIED orcid.org/0000-0002-0344-6281 UNSPECIFIED Bobkova, Marina UNSPECIFIED orcid.org/0000-0001-5481-8957 UNSPECIFIED Sierra, Saleta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-338134
DOI:	10.3390/v12040475
Journal or Publication Title:	Viruses-Basel
Volume:	12
Number:	4
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1999-4915
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FORMER SOVIET-UNION; DRUG-RESISTANCE; TYPE-1; DIVERSITY; MUTATIONS; EFAVIRENZ; COUNTRIES; VARIANTS; STRAINS; ORIGIN Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33813