Universität zu Köln

Torres, Raul, Stetter, Markus G. ORCID: 0000-0001-7136-0589, Hernandez, Ryan D. and Ross-Ibarra, Jeffrey ORCID: 0000-0003-1656-4954 (2020). The Temporal Dynamics of Background Selection in Nonequilibrium Populations. Genetics, 214 (4). S. 1019 - 1031. BETHESDA: GENETICS SOCIETY AMERICA. ISSN 1943-2631

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Abstract

Neutral genetic diversity across the genome is determined by the complex interplay of mutation, demographic history, and natural selection. While the direct action of natural selection is limited to functional loci across the genome, its impact can have effects on nearby neutral loci due to genetic linkage. These effects of selection at linked sites, referred to as genetic hitchhiking and background selection (BGS), are pervasive across natural populations. However, only recently has there been a focus on the joint consequences of demography and selection at linked sites, and some empirical studies have come to apparently contradictory conclusions as to their combined effects. To understand the relationship between demography and selection at linked sites, we conducted an extensive forward simulation study of BGS under a range of demographic models. We found that the relative levels of diversity in BGS and neutral regions vary over time and that the initial dynamics after a population size change are often in the opposite direction of the long-term expected trajectory. Our detailed observations of the temporal dynamics of neutral diversity in the context of selection at linked sites in nonequilibrium populations provide new intuition about why patterns of diversity under BGS vary through time in natural populations and help reconcile previously contradictory observations. Most notably, our results highlight that classical models of BGS are poorly suited for predicting diversity in nonequilibrium populations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Torres, Raul UNSPECIFIED UNSPECIFIED UNSPECIFIED Stetter, Markus G. UNSPECIFIED orcid.org/0000-0001-7136-0589 UNSPECIFIED Hernandez, Ryan D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ross-Ibarra, Jeffrey UNSPECIFIED orcid.org/0000-0003-1656-4954 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-338821
DOI:	10.1534/genetics.119.302892
Journal or Publication Title:	Genetics
Volume:	214
Number:	4
Page Range:	S. 1019 - 1031
Date:	2020
Publisher:	GENETICS SOCIETY AMERICA
Place of Publication:	BETHESDA
ISSN:	1943-2631
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DELETERIOUS MUTATIONS; MOLECULAR EVOLUTION; PURIFYING SELECTION; NATURAL-SELECTION; GENETIC-VARIATION; SIZE; RECOMBINATION; DOMESTICATION; DEMOGRAPHY; PATTERNS Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33882