Poirier, John T., George, Julie, Owonikoko, Taofeek K., Berns, Anton, Brambilla, Elisabeth, Byers, Lauren A., Carbone, David, Chen, Huanhuan J., Christensen, Camilla L., Dive, Caroline, Farago, Anna, Govindan, Ramaswamy, Hann, Christine, Hellmann, Matthew D., Horn, Leora, Johnson, Jane E., Ju, Young S., Kang, Sumin, Krasnow, Mark, Lee, James, Lee, Se-Hoon, Lehman, Jonathan, Lok, Benjamin, Lovly, Christine ORCID: 0000-0002-3641-6361, MacPherson, David, McFadden, David, Minna, John, Oser, Matthew, Park, Keunchil, Park, Kwon-Sik, Pommier, Yves, Quaranta, Vito, Ready, Neal, Sage, Julien, Scagliotti, Giorgio, Sos, Martin L., Sutherland, Kate D., Travis, William D., Vakoc, Christopher R., Wait, Sarah J., Wistuba, Ignacio, Wong, Kwok Kin, Zhang, Hua, Daigneault, Jillian, Wiens, Jacinta, Rudin, Charles M. and Oliver, Trudy G. (2020). New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J. Thorac. Oncol., 15 (4). S. 520 - 541. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1556-1380

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Abstract

The outcomes of patients with SCLC have not yet been substantially impacted by the revolution in precision oncology, primarily owing to a paucity of genetic alterations in actionable driver oncogenes. Nevertheless, systemic therapies that include immunotherapy are beginning to show promise in the clinic. Although, these results are encouraging, many patients do not respond to, or rapidly recur after, current regimens, necessitating alternative or complementary therapeutic strategies. In this review, we discuss ongoing investigations into the pathobiology of this recalcitrant cancer and the therapeutic vulnerabilities that are exposed by the disease state. Included within this discussion, is a snapshot of the current biomarker and clinical trial landscapes for SCLC. Finally, we identify key knowledge gaps that should be addressed to advance the field in pursuit of reduced SCLC mortality. This review largely summarizes work presented at the Third Biennial International Association for the Study of Lung Cancer SCLC Meeting. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Poirier, John T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
George, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owonikoko, Taofeek K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berns, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Byers, Lauren A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carbone, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Huanhuan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Christensen, Camilla L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dive, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farago, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Govindan, RamaswamyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hann, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellmann, Matthew D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, LeoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, Jane E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ju, Young S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kang, SuminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krasnow, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Se-HoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehman, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lok, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lovly, ChristineUNSPECIFIEDorcid.org/0000-0002-3641-6361UNSPECIFIED
MacPherson, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McFadden, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minna, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oser, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, KeunchilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Kwon-SikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pommier, YvesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaranta, VitoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ready, NealUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sage, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scagliotti, GiorgioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sos, Martin L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sutherland, Kate D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Travis, William D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vakoc, Christopher R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wait, Sarah J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wistuba, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wong, Kwok KinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, HuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daigneault, JillianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiens, JacintaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudin, Charles M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oliver, Trudy G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-339379
DOI: 10.1016/j.jtho.2020.01.016
Journal or Publication Title: J. Thorac. Oncol.
Volume: 15
Number: 4
Page Range: S. 520 - 541
Date: 2020
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1556-1380
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CELL LUNG-CANCER; CIRCULATING TUMOR-CELLS; PARP INHIBITOR; IN-VIVO; INDEPENDENT PREDICTOR; STEM-CELLS; OPEN-LABEL; HETEROGENEITY; COMBINATION; MUTATIONSMultiple languages
Oncology; Respiratory SystemMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33937

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