Wybranski, Christian, Siedek, Florian, Damm, Robert, Gazis, Angelos, Wenzel, Ortrud, Haneder, Stefan, Persigehl, Thorsten, Steinhauser, Susanne, Pech, Maciej, Fischbach, Frank and Fischbach, Katharina (2020). Respiratory motion artefacts in Gd-EOB-DTPA (Primovist/Eovist) and Gd-DOTA (Dotarem)-enhanced dynamic phase liver MRI after intensified and standard pre-scan patient preparation: A bi-institutional analysis. PLoS One, 15 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objective The objective of this study is to evaluate if intensified pre-scan patient preparation (IPPP) that comprises custom-made educational material on dynamic phase imaging and supervised pre-imaging breath-hold training in addition to standard informative conversation with verbal explanation of breath-hold commands (standard pre-scan patient preparationSPPP) might reduce the incidence of gadoxetate disodium (Gd-EOB-DTPA)-related transient severe respiratory motion (TSM) and severity of respiratory motion (RM) during dynamic phase liver MRI. Material and methods In this bi-institutional study 100 and 110 patients who received Gd-EOB-DTPA for dynamic phase liver MRI were allocated to either IPPP or SPPP at site A and B. The control group comprised 202 patients who received gadoterate meglumine (Gd-DOTA) of which each 101 patients were allocated to IPPP or SPPP at site B. RM artefacts were scored retrospectively in dynamic phase images (1: none-5: extensive) by five and two blinded readers at site A and B, respectively, and in the hepatobiliary phase of the Gd-EOB-DTPA-enhanced scans by two blinded readers at either site. Results The incidence of TSM was 15% at site A and 22.7% at site B (p = 0.157). IPPP did not reduce the incidence of TSM in comparison to SPPP: 16.7% vs. 21.6% (p = 0.366). This finding was consistent at site A: 12% vs. 18% (p = 0.401) and site B: 20.6% vs. 25% (p = 0.590). The TSM incidence in patients with IPPP and SPPP did not differ significantly between both sites (p = 0.227; p = 0.390). IPPP did not significantly mitigate RM in comparison to SPPP in any of the Gd-EOB-DTPA-enhanced dynamic phases and the hepatobiliary phase in patients without TSM (all p >= 0.072). In the Gd-DOTA control group on the other hand, IPPP significantly mitigated RM in all dynamic phases in comparison to SPPP (all p <= 0.031). Conclusions We conclude that Gd-EOB-DTPA-related TSM cannot be mitigated by education and training and that Gd-EOB-DTPA-related breath-hold difficulty does not only affect the subgroup of patients with TSM or exclusively the arterial phase as previously proposed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wybranski, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siedek, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damm, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gazis, AngelosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenzel, OrtrudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haneder, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Persigehl, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinhauser, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pech, MaciejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischbach, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischbach, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-340487
DOI: 10.1371/journal.pone.0230024
Journal or Publication Title: PLoS One
Volume: 15
Number: 3
Date: 2020
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEPATIC ARTERIAL PHASE; TRANSIENT SEVERE MOTION; DISODIUM-ENHANCED MRI; BREATH-HOLD TECHNIQUE; GADOXETATE DISODIUM; REDUCING ARTIFACTS; PRIOR EPISODE; ACID; INFORMATION; ACQUISITIONMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34048

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