Universität zu Köln

Sripad, Praveen ORCID: 0000-0001-6361-2571, Rosenberg, Jessica ORCID: 0000-0003-2688-9410, Boers, Frank, Filss, Christian P., Galldiks, Norbert ORCID: 0000-0002-2485-1796, Langen, Karl-Josef, Clauss, Ralf, Shah, N. Jon ORCID: 0000-0002-8151-6169 and Dammers, Juergen (2020). Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study. Case Rep. Neurol. Med., 2020. LONDON: HINDAWI LTD. ISSN 2090-6676

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Abstract

In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4-12 Hz) and lower beta (15-20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20-43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sripad, Praveen UNSPECIFIED orcid.org/0000-0001-6361-2571 UNSPECIFIED Rosenberg, Jessica UNSPECIFIED orcid.org/0000-0003-2688-9410 UNSPECIFIED Boers, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Clauss, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED Dammers, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340492
DOI:	10.1155/2020/8597062
Journal or Publication Title:	Case Rep. Neurol. Med.
Volume:	2020
Date:	2020
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2090-6676
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; REBOUND INSOMNIA; VEGETATIVE STATE; EEG; ALPHA; MAGNETOENCEPHALOGRAPHY; OSCILLATIONS; DISORDERS; NETWORKS; DYNAMICS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34049