Universität zu Köln

Koenigschulte, W., Civai, C., Hildebrand, P., Gaber, T. J., Fink, G. R. and Zepf, F. D. (2020). Effects of serotonin depletion and dopamine depletion on bimodal divided attention. World J. Biol. Psychiatry, 21 (3). S. 183 - 195. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412

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Abstract

Objectives: This study aimed to explore the effects of acute phenylalanine tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition. Methods: Fifty-three healthy adults (final analyzed sample was N = 49, age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 h. Blood samples were taken before and 6 h after challenge intake. Results: Amino acid concentrations following challenge intake significantly decreased (all P <= 0.01). There was a significant difference in the mean reaction time (RT) towards auditory stimuli, but not towards visual stimuli between the groups. Post-hoc comparison of mean RTs (auditory stimuli) showed a significant difference between ATD (RT = 604.0 ms, SD = 56.9 ms) and APTD (RT = 556.4 ms, SD = 54.2 ms; P = 0.037), but no RT difference between ATD and BAL or APTD and BAL (RT = 573.6 ms, SD = 45.7 ms). Conclusions: The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koenigschulte, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Civai, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hildebrand, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaber, T. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zepf, F. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340918
DOI:	10.1080/15622975.2018.1532110
Journal or Publication Title:	World J. Biol. Psychiatry
Volume:	21
Number:	3
Page Range:	S. 183 - 195
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1814-1412
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE TRYPTOPHAN DEPLETION; SPATIAL WORKING-MEMORY; BLOOD-BRAIN-BARRIER; TYROSINE DEPLETION; PREFRONTAL CORTEX; 5-HYDROXYINDOLEACETIC ACID; CATECHOLAMINE SYNTHESIS; DIETARY MANIPULATION; KYNURENINE PATHWAY; HEALTHY-VOLUNTEERS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34091