Universität zu Köln

Goepel, Wolfgang, Mueller, Mirja, Rabe, Heike ORCID: 0000-0002-2047-8875, Borgmann, Johannes, Rausch, Tanja K., Faust, Kirstin, Kribs, Angela, Doetsch, Joerg, Ellinghaus, David ORCID: 0000-0002-4332-6110, Haertel, Christoph, Roll, Claudia, Szabo, Miklos, Nuernberg, Peter, Franke, Andre, Koenig, Inke R., Turner, Mark A. and Herting, Egbert (2020). Genetic background of high blood pressure is associated with reduced mortality in premature neonates. Arch. Dis. Child.-Fetal Neonatal Ed., 105 (2). S. F184 - 6. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2052

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Abstract

Objective The aim of our study was to determine if a genetic background of high blood pressure is a survival factor in preterm infants. Design Prospective cohort study. Setting Patients were enrolled in 53 neonatal intensive care units. Patients Preterm infants with a birth weight below 1500 g. Exposures Genetic score blood pressure estimates were calculated based on adult data. We compared infants with high genetic blood pressure estimates (>75th percentile of the genetic score) to infants with low genetic blood pressure estimates (<25th percentile of the genetic score). Main outcome measures Lowest blood pressure on the first day of life and mortality. Results 5580 preterm infants with a mean gestational age of 28.1 +/- 2.2 weeks and a mean birth weight of 1022 +/- 299 g were genotyped and analysed. Infants with low genetic blood pressure estimates had significantly lower blood pressure if compared with infants with high genetic blood pressure estimates (27.3 +/- 6.2vs 27.9 +/- 6.4, p=0.009, t-test). Other risk factors for low blood pressure included low gestational age (-1.26 mm Hg/week) and mechanical ventilation (-2.24 mm Hg, p<0.001 for both variables, linear regression analysis). Mortality was significantly reduced in infants with high genetic blood pressure estimates (28-day mortality: 21/1395, 1.5% vs 44/1395, 3.2%, p=0.005, Fisher's exact test). This survival advantage was independent of treatment with catecholamines. Conclusions Our study provides first evidence that a genetic background of high blood pressure may be beneficial with regard to survival of preterm infants.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goepel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Mirja UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabe, Heike UNSPECIFIED orcid.org/0000-0002-2047-8875 UNSPECIFIED Borgmann, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Rausch, Tanja K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faust, Kirstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellinghaus, David UNSPECIFIED orcid.org/0000-0002-4332-6110 UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Roll, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Szabo, Miklos UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Inke R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Turner, Mark A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herting, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-341974
DOI:	10.1136/archdischild-2019-317131
Journal or Publication Title:	Arch. Dis. Child.-Fetal Neonatal Ed.
Volume:	105
Number:	2
Page Range:	S. F184 - 6
Date:	2020
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2052
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIRTH-WEIGHT INFANTS; PRETERM INFANTS; TREATED HYPOTENSION; HEMORRHAGE; OUTCOMES; THERAPY; AGE Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34197