Universität zu Köln

Ophey, Anja ORCID: 0000-0001-5858-7762, Giehl, Kathrin, Rehberg, Sarah, Eggers, Carsten, Reker, Paul, van Eimeren, Thilo and Kalbe, Elke (2020). Effects of working memory training in patients with Parkinson's disease without cognitive impairment: A randomized controlled trial. Parkinsonism Relat. Disord., 72. S. 13 - 23. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Objective: To determine the feasibility and evaluate effects of a computerized working memory (WM) training (WMT) in patients with Parkinson's Disease (PD) on cognitive and clinical outcomes. Methods: 76 patients with PD without cognitive impairment were randomized to either the WMT group (n = 37), who participated in a 5-week adaptive WMT, or a passive waiting-list control group (CG, n = 39). Patients underwent clinical and neuropsychological examination at baseline, after training, and at 3-months follow-up, with verbal WM and non-verbal WM as primary outcomes. Outcome assessors were blinded for group allocation. Results: All WMT participants completed the training successfully and reported high levels of motivation for and satisfaction with the training. Repeated-measures, linear mixed-effects models revealed positive training effects for the WMT group compared to the CG in verbal working memory with a small relative effect size 0.39 [95%CI 0.05; 0.76] for the 3-months follow-up only. No other reliable training effects in cognitive and clinical variables were found for either point of time. Conclusions: In this randomized controlled trial, WMT was feasible and yielded some evidence for 3-months follow-up training gains in patients with PD. WMT might be an effective intervention to prevent cognitive decline in this patient group, however, more longitudinal studies with longer follow-up periods and more sensitive assessment tools will have to proof this concept.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ophey, Anja UNSPECIFIED orcid.org/0000-0001-5858-7762 UNSPECIFIED Giehl, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Reker, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-342251
DOI:	10.1016/j.parkreldis.2020.02.002
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	72
Page Range:	S. 13 - 23
Date:	2020
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEMENTIA; ADULTS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34225