Universität zu Köln

Turpin-Nolan, Sarah M. and Bruening, Jens C. (2020). The role of ceramides in metabolic disorders: when size and localization matters. Nat. Rev. Endocrinol., 16 (4). S. 224 - 234. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1759-5037

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Abstract

This Review examines the emerging concept that distinct ceramide species in specific cellular compartments can exert specialized functions in obesity-associated deterioration of metabolic homeostasis. Ceramides are therefore potential targets in the development of novel and specific therapies for obesity and obesity-associated diseases. Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s, ceramides were viewed as a homogenous class of sphingolipids. However, it has now become clear that ceramides exert fundamentally different effects depending on the specific fatty acyl chain lengths, which are integrated into ceramides by a group of enzymes known as dihydroceramide synthases. In addition, alterations in ceramide synthesis, trafficking and metabolism in specific cellular compartments exert distinct consequences on metabolic homeostasis. Here, we examine the emerging concept of how the intracellular localization of ceramides with distinct acyl chain lengths can regulate glucose metabolism, thus emphasizing their potential as targets in the development of novel and specific therapies for obesity and obesity-associated diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Turpin-Nolan, Sarah M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-344851
DOI:	10.1038/s41574-020-0320-5
Journal or Publication Title:	Nat. Rev. Endocrinol.
Volume:	16
Number:	4
Page Range:	S. 224 - 234
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1759-5037
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOPLASMIC-RETICULUM STRESS; SATURATED FATTY-ACIDS; SKELETAL-MUSCLE; ER STRESS; INSULIN-RESISTANCE; SYNTHASE 2; TRIACYLGLYCEROL ACCUMULATION; NONVESICULAR TRAFFICKING; SPHINGOLIPID METABOLISM; GLUCOSE-HOMEOSTASIS Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34485