Universität zu Köln

Dembek, Till A., Petry-Schmelzer, Jan Niklas ORCID: 0000-0003-0749-3840, Reker, Paul, Wirths, Jochen, Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Steffen, Julia, Dafsari, Haidar S., Hoevels, Mauritius, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Visser-Vandewalle, Veerle and Barbe, Michael T. (2020). PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract. NeuroImage-Clin., 26. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Objective: To investigate the relation between deep brain stimulation (DBS) of the posterior-subthalamic-area (PSA) and the ventral-intermediate-nucleus (VIM) and the distance to the dentatorubrothalamic tract (DRTT) in essential tremor (ET). Methods: Tremor rating scale (TRS) hemi-scores were analyzed in 13 ET patients, stimulated in both the VIM and the PSA in a randomized, crossover trial. Distances of PSA and VIM contacts to population-based DRTTs were calculated. The relationships between distance to DRTT and stimulation amplitude, as well as DBS efficiency (TRS improvement per amplitude) were investigated. Results: PSA contacts were closer to the DRTT (p = 0.019) and led to a greater improvement in TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to the DRTT was related to lower amplitudes (p < 0.001) and higher DBS efficiency (p = 0.017). Conclusions: Differences in tremor outcome and stimulation parameters between contacts in the PSA and the VIM can be explained by their different distance to the DRTT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, Jan Niklas UNSPECIFIED orcid.org/0000-0003-0749-3840 UNSPECIFIED Reker, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirths, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Steffen, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoevels, Mauritius UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350872
DOI:	10.1016/j.nicl.2020.102235
Journal or Publication Title:	NeuroImage-Clin.
Volume:	26
Date:	2020
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; SUBTHALAMIC AREA; NUCLEUS; TRACTOGRAPHY Multiple languages Neuroimaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35087