Universität zu Köln

Curth, Harald-Morten, Dinter, Johanna, Nigemeier, Kerstin, Kuetting, Fabian, Hunzelmann, Nicolas and Steffen, Hans-Michael (2015). Effects of Helicobacter pylori Eradication in Chronic Spontaneous Urticaria: Results from a Retrospective Cohort Study. Am. J. Clin. Dermatol., 16 (6). S. 553 - 559. NORTHCOTE: ADIS INT LTD. ISSN 1179-1888

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Abstract

Background and Objective Helicobacter pylori (Hp) infection has been hypothesised to play a major role in the pathogenesis of chronic spontaneous urticaria (CSU). Despite only weak evidence from Hp eradication studies, screening for Hp infection is still recommended in several CSU guidelines. The aim of this study was to investigate the effect of Hp eradication in combination with standard CSU treatment in Hp-positive compared with Hp-negative patients, applying the latest guidelines for both diseases. Methods 138 consecutive patients with CSU were enrolled in this retrospective cohort study. All patients underwent gastroscopy and Hp status was determined by urease testing and histologic examination. Seventy-five patients were diagnosed as Hp negative and 47 patients fulfilled criteria for definite Hp infection, 45 of whom received eradication therapy. Sixteen patients who received eradication therapy without an appropriate indication served as the medication control. All patients received symptomatic treatment with antihistamines and/or glucocorticoids regardless of Hp status. Partial response (PR) was defined as subjective amelioration of CSU symptoms; patients returning for further CSU treatment within 6 months were considered non-responders/relapsers (NRs). Results The prevalence of Hp infection was comparable with Hp seroprevalence data reported for healthy western populations. Standard treatment of CSU led to relief of symptoms independent of Hp status. Hp eradication by standard triple therapy had no additional effect on PR (p = 0.32) or NR (p = 0.50). Conclusions Hp eradication has no discernible effect on CSU beyond that of standard CSU therapy. Therefore, Hp eradication should only be initiated in accordance with currently accepted indications of Hp treatment guidelines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Curth, Harald-Morten UNSPECIFIED UNSPECIFIED UNSPECIFIED Dinter, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Nigemeier, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuetting, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunzelmann, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, Hans-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385295
DOI:	10.1007/s40257-015-0152-6
Journal or Publication Title:	Am. J. Clin. Dermatol.
Volume:	16
Number:	6
Page Range:	S. 553 - 559
Date:	2015
Publisher:	ADIS INT LTD
Place of Publication:	NORTHCOTE
ISSN:	1179-1888
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC IDIOPATHIC URTICARIA; SERUM SKIN-TEST; CONSENSUS REPORT; INFECTION; AUTOIMMUNITY; DIAGNOSIS; CLASSIFICATION; DEFINITION; PREVALENCE; ACTIVATION Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38529