Monge, S., Jarrin, I., Mocroft, A., Sabin, C. A., Touloumi, G., van Sighem, A., Abgrall, S., Dray-Spira, R., Spire, B., Castagna, A., Mussini, C., Zangerle, R., Hessamfar, M., Anderson, J., Hamouda, O., Ehren, K., Obel, N., Kirk, O., de Monteynard, L. A., Antinori, A., Girardi, E., Saracino, A., Calmy, A., De Wit, S., Wittkop, L., Bucher, H. C., Montoliu, A., Raben, D., Prins, M., Meyer, L., Chene, G., Burns, F. and Del Amo, J. (2015). Mortality in migrants living with HIV in western Europe (1997-2013): a collaborative cohort study. Lancet HIV, 2 (12). S. E540 - 10. SAN DIEGO: ELSEVIER INC. ISSN 2352-3018

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Abstract

Background Many migrants face adverse socioeconomic conditions and barriers to health services that can impair timely HIV diagnosis and access to life-saving treatments. We aimed to assess the differences in overall mortality by geographical origin in HIV-positive men and women using data from COHERE, a large European collaboration of HIV cohorts from 1997 to 2013. Methods In this observational cohort study, we included HIV-positive, antiretroviral-naive people accessing care in western Europe from COHERE. Individuals were eligible if enrolled in a cohort that collected information on geographical origin or ethnic origin from Jan 1, 1997, to March 19, 2013, aged 18-75 years, they had available information about sex, they were not infected perinatally or after the receipt of clotting factor concentrates, and were naive to combination antiretroviral therapy at cohort entry. Migrants' origins were grouped into seven regions: western Europe and similar countries (Australia, Canada, New Zealand, and the USA); eastern Europe; North Africa and the Middle East; sub-Saharan Africa; Latin America; the Caribbean; and Asia and the rest of Oceania (excluding Australia and New Zealand). Crude and adjusted mortality rate ratios were calculated by use of Poisson regression stratified by sex, comparing each group with the native population. Multiple imputation with chained equations was used to account for missing values. Findings Between Oct 25, 1979, and March 19, 2013, we recruited 279 659 individuals to the COHERE collaboration in EuroCoord. Of these 123 344 men and 45 877 women met the inclusion criteria. Our data suggested effect modification by transmission route (p(interaction) = 0.12 for men; p (interaction) = 0.002 for women). No significant difference in mortality was identified by geographical origin in men who have sex with men. In heterosexual populations, most migrant men had mortality lower than or equal to that of native men, whereas no group of migrant women had mortality lower than that in native women. High mortality was identified in heterosexual men from Latin America (rate ratio [RR] 1.46, 95% CI 1.00-2.12, p= 0.049) and heterosexual women from the Caribbean (1.48, 1.29-1.70, p< 0.0001). Compared with that in the native population, mortality in injecting drug users was similar or low for all migrant groups. Interpretation Characteristics of and risks faced by migrant populations with HIV differ for men and women and for populations infected heterosexually, by sex between men, or by injecting drug use. Further research is needed to understand how inequalities are generated and maintained for the groups with higher mortality identified in this study.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Monge, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarrin, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabin, C. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Touloumi, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Sighem, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abgrall, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dray-Spira, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spire, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagna, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mussini, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zangerle, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hessamfar, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderson, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamouda, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehren, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obel, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirk, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Monteynard, L. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antinori, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Girardi, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saracino, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calmy, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Wit, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittkop, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bucher, H. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montoliu, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raben, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prins, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chene, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burns, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Amo, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-386230
DOI: 10.1016/S2352-3018(15)00203-9
Journal or Publication Title: Lancet HIV
Volume: 2
Number: 12
Page Range: S. E540 - 10
Date: 2015
Publisher: ELSEVIER INC
Place of Publication: SAN DIEGO
ISSN: 2352-3018
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMBINATION ANTIRETROVIRAL THERAPY; SUB-SAHARAN AFRICA; DISEASE PROGRESSION; HIV-1-INFECTED PATIENTS; HEALTH INEQUALITIES; GENDER; POPULATIONS; COUNTRIES; DEATH; AIDSMultiple languages
Immunology; Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38623

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