Universität zu Köln

Nyuchev, Alexander V., Otvagin, Vasiliy F., Gavryushin, Andrei E., Romanenko, Yuliya I., Koifman, Oscar I., Belykh, Dmitrii V., Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 and Fedorov, Alexey Yu. ORCID: 0000-0003-4889-8617 (2015). Synthesis of Chlorin-(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development. Synthesis, 47 (23). S. 3717 - 3727. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1437-210X

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Abstract

A series of multifunctional conjugates each consisting of a fluorescent chlorin photosensitizer and an (arylamino)quinazoline-based epidermal growth factor receptor/vascular endothelial growth factor receptor ligand, potentially useful in site-selective photodynamic antitumor therapy, were prepared and their photochemical properties were investigated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nyuchev, Alexander V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Otvagin, Vasiliy F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gavryushin, Andrei E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Romanenko, Yuliya I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koifman, Oscar I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Belykh, Dmitrii V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED Fedorov, Alexey Yu. UNSPECIFIED orcid.org/0000-0003-4889-8617 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386474
DOI:	10.1055/s-0034-1378876
Journal or Publication Title:	Synthesis
Volume:	47
Number:	23
Page Range:	S. 3717 - 3727
Date:	2015
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1437-210X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECEPTOR TYROSINE KINASE; TETRA-HYDROXYPHENYL-CHLORIN; PHOTODYNAMIC THERAPY; CLICK CHEMISTRY; IN-VIVO; COMBINATION CHEMOTHERAPY; CHLOROPHYLL DERIVATIVES; CYTOTOXIC ACTIVITY; OPTICAL-PROPERTIES; ANTITUMOR AGENTS Multiple languages Chemistry, Organic Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/38647