Universität zu Köln

Kohl, S., Gruendler, T. O. J., Huys, D., Sildatke, E., Dembek, T. A., Hellmich, M., Vorderwulbecke, M., Timmermann, L., Ahmari, S. E., Klosterkoetter, J., Jessen, F., Sturm, V., Visser-Vandewalle, V. and Kuhn, J. (2015). Effects of deep brain stimulation on prepulse inhibition in obsessive-compulsive disorder. Transl. Psychiatr., 5. NEW YORK: NATURE PUBLISHING GROUP. ISSN 2158-3188

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Abstract

Owing to a high response rate, deep brain stimulation (DBS) of the ventral striatal area has been approved for treatment-refractory obsessive-compulsive disorder (tr-OCD). Many basic issues regarding DBS for tr-OCD are still not understood, in particular, the mechanisms of action and the origin of side effects. We measured prepulse inhibition (PPI) in treatment-refractory OCD patients undergoing DBS of the nucleus accumbens (NAcc) and matched controls. As PPI has been used in animal DBS studies, it is highly suitable for translational research. Eight patients receiving DBS, eight patients with pharmacological treatment and eight age-matched healthy controls participated in our study. PPI was measured twice in the DBS group: one session with the stimulator switched on and one session with the stimulator switched off. OCD patients in the pharmacologic group took part in a single session. Controls were tested twice, to ensure stability of data. Statistical analysis revealed significant differences between controls and (1) patients with pharmacological treatment and (2) OCD DBS patients when the stimulation was switched off. Switching the stimulator on led to an increase in PPI at a stimulus-onset asynchrony of 200 ms. There was no significant difference in PPI between OCD patients being stimulated and the control group. This study shows that NAcc-DBS leads to an increase in PPI in tr-OCD patients towards a level seen in healthy controls. Assuming that PPI impairments partially reflect the neurobiological substrates of OCD, our results show that DBS of the NAcc may improve sensorimotor gating via correction of dysfunctional neural substrates. Bearing in mind that PPI is based on a complex and multilayered network, our data confirm that DBS most likely takes effect via network modulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kohl, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruendler, T. O. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sildatke, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, T. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vorderwulbecke, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahmari, S. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-387085
DOI:	10.1038/tp.2015.171
Journal or Publication Title:	Transl. Psychiatr.
Volume:	5
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	2158-3188
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACOUSTIC STARTLE; IN-VIVO; PSYCHIATRIC-DISORDERS; DOUBLE-BLIND; DOPAMINE; NUCLEUS; SCHIZOPHRENIA; REFLEX; MODULATION; SEROTONIN Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38708