Universität zu Köln

Halbach, M., Fritz, T., Madershahia, N., Pfister, R. and Reuter, H. (2015). Baroreflex activation therapy. A novel interventional approach to treat heart failure with reduced ejection fraction. Herz, 40 (7). S. 959 - 966. MUNICH: URBAN & VOGEL. ISSN 1615-6692

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Abstract

Sympathovagal imbalance plays an important role in the progression of heart failure with reduced ejection fraction. Baroreflex activation therapy (BAT), i. e. electrical stimulation of baroreceptors located at the carotid sinus, can reduce sympathetic and enhance parasympathetic tone. Large animal studies on BAT demonstrated improvements in cardiac function, arrhythmogenic risk and a survival benefit compared to untreated controls. The recently published Neo Randomized Heart Failure Study, the first multicenter, randomized and controlled trial of optimal medical and device therapy alone or plus BAT in patients with a left ventricular ejection fraction 35%, demonstrated a reasonable safety profile of BAT in this severely ill patient population and no relevant interactions with other devices. The study found significant improvements in the NewYork Heart Association (NYHA) class of heart failure, quality of life as well as 6 min walking distance and data pointed to a reduction in hospitalization rates. Moreover, N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly reduced. This review gives an overview on BAT for the treatment of heart failure with reduced ejection fraction, from the rationale and animal experiments to the most recent clinical data and future perspectives.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Halbach, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritz, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Madershahia, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-387715
DOI:	10.1007/s00059-015-4361-9
Journal or Publication Title:	Herz
Volume:	40
Number:	7
Page Range:	S. 959 - 966
Date:	2015
Publisher:	URBAN & VOGEL
Place of Publication:	MUNICH
ISSN:	1615-6692
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CAROTID-SINUS NERVES; RESISTANT HYPERTENSION; ELECTRICAL STIMULATION; EFFICACY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38771