Universität zu Köln

Safi, Ali-Farid, Nickenig, Hans-Joachim, Rothamel, Daniel, Zirk, Matthias, Thiele, Oliver ORCID: 0000-0001-5958-9583, Grandoch, Andrea, Scheer, Martin, Zinser, Max, Zoeller, Joachim, Drebber, Uta and Kreppel, Matthias (2015). Expression of ezrin in oral squamous cell carcinoma: Prognostic impact and clinicopathological correlations. J. Cranio-MaxilloFac. Surg., 43 (9). S. 1899 - 1906. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

Introduction: There have been few investigations into the effects of ezrin expression in oral squamous cell carcinoma (OSCC). The aim of this study was to analyze the influence of ezrin expression on the prognosis of patients with OSCC. Materials and methods: Eighty patients were included in the retrospective study. Expression and localization of ezrin were evaluated using immunohistochemistry. Associations were identified using chi(2) tests. Prognostic factors were identified by univariate and multivariate analysis. Results: Seventy-six (95%) patients showed ezrin expression. Ezrin expression had a significant impact on overall survival (OS) (p < 0.001). With increasing expression, the 5-year OS rate dropped from 100% for ezrin-negative patients to 47% for patients with high expression. Multivariate analysis confirmed the significant influence of ezrin expression on OS (p = 0.011). Cytoplasmic localization of ezrin led to a significantly lower survival rate in comparison with membranous expression. Conclusions: Ezrin may serve as a biomarker that predicts biologically aggressive behavior of OSCC and hence improves therapeutic techniques and the prognosis of patients affected with the disease. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Zirk, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Oliver UNSPECIFIED orcid.org/0000-0001-5958-9583 UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zinser, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388243
DOI:	10.1016/j.jcms.2015.08.011
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	43
Number:	9
Page Range:	S. 1899 - 1906
Date:	2015
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ERM PROTEINS; ALTERED EXPRESSION; MOLECULAR MARKERS; CANCER; METASTASIS; SURVIVAL; HEAD; ADENOCARCINOMA; MOESIN; CORTEX Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38824