Universität zu Köln

Veronica, Di Cristanziano, Sindy, Boettcher, Sabine, Diedrich, Monika, Timmen-Wego, Elena, Knops, Nadine, Luebke, Rolf, Kaiser, Herbert, Pfister, Yolande, Kabore and Rossella, D'Alfonso (2015). Detection and characterization of enteroviruses and parechoviruses in healthy people living in the South of Cote d'Ivoire. J. Clin. Virol., 71. S. 40 - 44. AMSTERDAM: ELSEVIER. ISSN 1873-5967

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Abstract

Background: Human enteroviruses (EVs) and parechoviruses (HPeVs) belong to the family Picornaviridae. Although most EV and HPeV infections remain asymptomatic, both pathogens can cause a wide spectrum of clinical manifestations ranging from respiratory or gastrointestinal symptoms to myocarditis, neonatal sepsis, and infections of the central nervous system. Objectives: Aim of the present study was to investigate the spectrum of EVs and HPeVs in apparently healthy adults and children living in the South of Cote d'Ivoire. Study design: The study included 105 stool samples obtained from healthy individuals aged 0-53 years between June 2013 and December 2014 in the Sud-Como region of Cote d'Ivoire. After collection and shipment to Germany, the samples were analyzed by real-time PCR for the presence of EVs and HPeVs RNA. Molecular typing and virus isolation of all samples were performed.e Results: Out of 105 samples, 24 (22.8%) were EV positive and six (5.2%) were HPeV positive. Twenty-one EV positive samples could be characterized with serotypes belonging to EV group A-C, while three could not be further specified. Interestingly, several rarely described serotypes were identified, e.g., EV-C99, EV-B93, EV-C116, and EV-A119. Typing of HPeV positive samples resulted in HPeV-1 and -5 detections, while one isolate could not be assigned to the known HPeV types. Conclusions: This study showed a large variety of EV strains in healthy people in the South of Cote d'Ivoire and provided the first available data about HPeV infections in a sub-Saharan African country. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Veronica, Di Cristanziano UNSPECIFIED UNSPECIFIED UNSPECIFIED Sindy, Boettcher UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabine, Diedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Monika, Timmen-Wego UNSPECIFIED UNSPECIFIED UNSPECIFIED Elena, Knops UNSPECIFIED UNSPECIFIED UNSPECIFIED Nadine, Luebke UNSPECIFIED UNSPECIFIED UNSPECIFIED Rolf, Kaiser UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbert, Pfister UNSPECIFIED UNSPECIFIED UNSPECIFIED Yolande, Kabore UNSPECIFIED UNSPECIFIED UNSPECIFIED Rossella, D'Alfonso UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-391779
DOI:	10.1016/j.jcv.2015.08.004
Journal or Publication Title:	J. Clin. Virol.
Volume:	71
Page Range:	S. 40 - 44
Date:	2015
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-5967
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIRECT IDENTIFICATION; CEREBROSPINAL-FLUID; PICORNAVIRUS; SEROTYPES; CAMEROON; AMPLIFICATION; DIVERSITY; CHILDREN Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39177