Otipoby, Kevin L., Waisman, Ari ORCID: 0000-0003-4304-8234, Derudder, Emmanuel ORCID: 0000-0003-1421-4045, Srinivasan, Lakshmi, Franklin, Andrew and Rajewsky, Klaus ORCID: 0000-0002-6633-6370 (2015). The B-cell antigen receptor integrates adaptive and innate immune signals. Proc. Natl. Acad. Sci. U. S. A., 112 (39). S. 12145 - 12151. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Full text not available from this repository.

Abstract

B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3 beta and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Otipoby, Kevin L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waisman, AriUNSPECIFIEDorcid.org/0000-0003-4304-8234UNSPECIFIED
Derudder, EmmanuelUNSPECIFIEDorcid.org/0000-0003-1421-4045UNSPECIFIED
Srinivasan, LakshmiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franklin, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajewsky, KlausUNSPECIFIEDorcid.org/0000-0002-6633-6370UNSPECIFIED
URN: urn:nbn:de:hbz:38-392618
DOI: 10.1073/pnas.1516428112
Journal or Publication Title: Proc. Natl. Acad. Sci. U. S. A.
Volume: 112
Number: 39
Page Range: S. 12145 - 12151
Date: 2015
Publisher: NATL ACAD SCIENCES
Place of Publication: WASHINGTON
ISSN: 0027-8424
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MOUSE IMMUNOGLOBULIN ANTIBODIES; LYMPHOCYTE DEVELOPMENT; KAPPA-B; GENE; ACTIVATION; KINASE; EXPRESSION; RESPONSES; SURVIVAL; PATHWAYMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39261

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item