Lueken, Ulrike ORCID: 0000-0003-1564-4012, Straube, Benjamin ORCID: 0000-0002-9837-0944, Yang, Yunbo, Hahn, Tim ORCID: 0000-0002-8929-4134, Beesdo-Baum, Katja, Wittchen, Hans-Ulrich ORCID: 0000-0002-6311-7711, Konrad, Carsten, Stroehle, Andreas, Wittmann, Andre, Gerlach, Alexander L. ORCID: 0000-0001-6794-5349, Pfleiderer, Bettina, Arolt, Volker and Kircher, Tilo ORCID: 0000-0002-2514-2625 (2015). Separating depressive comorbidity from panic disorder: A combined functional magnetic resonance imaging and machine learning approach. J. Affect. Disord., 184. S. 182 - 193. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1573-2517

Full text not available from this repository.

Abstract

Background: Depression is frequent in panic disorder (PD); yet, little is known about its influence on the neural substrates of PD. Difficulties in fear inhibition during safety signal processing have been reported as a pathophysiological feature of PD that is attenuated by depression. We investigated the impact of comorbid depression in PD with agoraphobia (AG) on the neural correlates of fear conditioning and the potential of machine learning to predict comorbidity status on the individual patient level based on neural characteristics. Methods: Fifty-nine PD/AG patients including 26 (44%) with a comorbid depressive disorder (PD/AG+DEP) underwent functional magnetic resonance imaging (fMRI). Comorbidity status was predicted using a random undersampling tree ensemble in a leave-one-out cross validation framework. Results: PD/AG-DEP patients showed altered neural activation during safety signal processing, while DEP patients exhibited generally decreased dorsolaleral prefrontal and insular activation. Comorbidity status was correctly predicted in 79% of patients (sensitivity: 73%; specificity: 85%) based on brain activation during fear conditioning (corrected for potential confounders: accuracy: 73%; sensitivity: 77%; specificity: 70%). Limitations: No primary depressed patients were available; only medication free patients were included. Major depression and dysthymia were collapsed (power considerations). Conclusions: Neurofunctional activation during safety signal processing differed between patients with or without comorbid depression, a Finding which may explain heterogeneous results across previous studies. These Findings demonstrate the relevance of comorbidity when investigating neurofunctional substrates of anxiety disorders. Predicting individual comorbidity status may translate neurofunctional data into clinically relevant information which might aid in planning individualized treatment. The study was registered with the ISRCTN: ISRCTN80046034. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lueken, UlrikeUNSPECIFIEDorcid.org/0000-0003-1564-4012UNSPECIFIED
Straube, BenjaminUNSPECIFIEDorcid.org/0000-0002-9837-0944UNSPECIFIED
Yang, YunboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahn, TimUNSPECIFIEDorcid.org/0000-0002-8929-4134UNSPECIFIED
Beesdo-Baum, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDorcid.org/0000-0002-6311-7711UNSPECIFIED
Konrad, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stroehle, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittmann, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, Alexander L.UNSPECIFIEDorcid.org/0000-0001-6794-5349UNSPECIFIED
Pfleiderer, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arolt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kircher, TiloUNSPECIFIEDorcid.org/0000-0002-2514-2625UNSPECIFIED
URN: urn:nbn:de:hbz:38-392988
DOI: 10.1016/j.jad.2015.05.052
Journal or Publication Title: J. Affect. Disord.
Volume: 184
Page Range: S. 182 - 193
Date: 2015
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1573-2517
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COGNITIVE-BEHAVIORAL THERAPY; SUPPORT VECTOR MACHINE; TREATMENT RESPONSE; MAJOR DEPRESSION; CONDITIONED FEAR; MRI DATA; AGORAPHOBIA; ANXIETY; FMRI; ACTIVATIONMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39298

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item