Fandrey, J. and Hallek, M. (2015). Erythropoiesis. Physiology, pathophysiology, and algorithm for classification of the type of anemia. Internist, 56 (9). S. 970 - 975. NEW YORK: SPRINGER. ISSN 1432-1289

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Abstract

Erythropoiesis is a continuous process that replaces 1 % of all erythrocytes per day. To keep the erythrocyte count within stable limits about 3 million cells/s must be renewed. This enormous turnover requires folic acid and vitamin B-12 for proper cell differentiation and iron for sufficient haemoglobin synthesis. In particular, iron metabolism underlies a precise regulation which may be disturbed by chronic bleeding, inflammatory disease or impaired dietary intake. If the loss of red blood cells due to physiological aging or bleeding is not balanced by sufficient erythropoiesis in the bone marrow, anaemia will develop. For the classification of various types of anaemia, a well-established algorithm has been proven useful. This algorithm addresses basic questions such as erythrocyte volume, the underlying mechanism, e.g. whether too many cells are destroyed or new cells are not sufficiently generated, and finally aims to define the main causes for the above identified disturbance of erythropoiesis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fandrey, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-394521
DOI: 10.1007/s00108-015-3712-1
Journal or Publication Title: Internist
Volume: 56
Number: 9
Page Range: S. 970 - 975
Date: 2015
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1289
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYSTEMIC IRON HOMEOSTASIS; EXPRESSION; TISSUEMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39452

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